Home > Inhibitors & Agonists > Metabolic Enzyme/Protease > Guanylate Cyclase
Cat. No. Product name CAS No.
DC11995 BI 703704

A novel potent soluble guanylate cyclase (sGC) activator.

1423067-48-4
DC11904 Olinciguat (IW-1701) Featured

Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay.

1628732-62-6
DC7782 BAY 41-2272

BAY 41-2272 is a soluble guanylate cyclase agonist, activates human mononuclear phagocytes

256376-24-6
DC7787 NS-2028

NS 2028 is a specific inhibitor of soluble guanylyl cyclase.

204326-43-2
DC11526 Praliciguat Featured

Praliciguat (IW-1973, IW1973) is a potent, orally available sGC stimulator that concentration-dependently increases the production of cGMP with EC50 of 267 nM.

1628730-49-3
DC7720 YC-1(Lificiguat) Featured

YC-1(Lificiguat) is a soluble guanylyl cyclase(sGC) activator; binds to the heme-containing domain of the β subunit with Kd value of 0.6-1.1 μM in the presence of CO.

170632-47-0
DC40112 Plecanatide

Plecanatide, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide shows anti-inflammatory activity in models of murine colitis.

467426-54-6
DC41629 Guanylin(human)

Guanylin(human), a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator. Guanylin(human) is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism.

183200-12-6
DC41630 Guanylin(human) TFA

Guanylin(human) TFA, a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator. Guanylin(human) TFA is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism.

DC44916 Guanylate cyclase-IN-1

Guanylate cyclase-IN-1 (Example 46) is a guanylate cyclase inhibitor that can be used for cardiovascular diseases research.

1361569-23-4
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