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Home > Inhibitors & Agonists > Ras-Raf-MAPK-ERK > Mixed Lineage Kinase (MLK)

Mixed Lineage Kinase (MLK)

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Cat. No. Product Name Field of Application Chemical Structure
DC43988 GW806742X hydrochloride
GW806742X hydrochloride, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a Kd of 9.3 μM. GW806742X hydrochloride has activity against VEGFR2 (IC50=2 nM). GW806742X hydrochlorid
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DC74345 TC13172
TC13172 (TC 13172) is a highly potent necroptosis inhibitor targeting the mixed lineage kinase domain-like protein (MLKL), inhibits necroptosis with IC50 of 2 nM in TSZ-induced necroptosis assays in HT-29 cells.
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DC74344 KC-130
KC-130 (KC130, ZAK inhibitor 8) is a potent, selective and covalent leucine-zipper and sterile-α motif kinase (ZAK) inhibitor with IC50 of 11.5 nM.
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DC7889 URMC-099 Featured
URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively, and also inhibits LRRK2 activity with IC50 of 11 nM.
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DC9817 Necrosulfonamide (NSA) Featured
Necrosulfonamide (NSA) is a very specific and potent necrosis inhibitor with an IC50 less than 0.2 uM.
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DC10503 GW806742X Featured
GW806742X is a novel VEGFR inhibitor.
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DC72550 NecroIr1
NecroIr1 is an iridium(III) complex, serves as necroptosis inducers in Cisplatin-resistant lung cancer cells (A549R). NecroIr1 selectively accumulates in mitochondria, leading to oxidative stress and loss of mitochondrial membrane potential (MMP). NecroIr1 activates receptor-interacting serine-threonine kinase 3 (RIPK3) and Mixed Lineage Kinase (MLKL), and regulates CDK4 expression.
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DC47569 MLKL-IN-1
MLKL-IN-1 is a covalent MLKL inhibitor with a KD of 50 μM.
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