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Home > PROTACs > E3 Ligase Ligand-Linker Conjugate

E3 Ligase Ligand-Linker Conjugate

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Cat. No. Product Name Field of Application Chemical Structure
DC45705 Thalidomide-NH-PEG1-NH2 hydrochloride Featured
Thalidomide-NH-PEG1-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
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DC28654 NH2-PEG6-Boc Featured
NH2-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG6-Boc is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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DC22869 E3 Ligand-Linker Conjugate 3(E3 Ligase Ligand-Linker Conjugates 19) Featured
An E3 ligase ligand-linker conjugate for PROTAC.
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DC50059 (S,R,S)-AHPC-C4-NH2 Featured
(S,R,S)-AHPC-C4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-Targeted PROTAC[1].
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DC50057 E3 ligase Ligand-Linker Conjugates 30 Featured
E3 ligase Ligand-Linker Conjugates 30 incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 30 can be used to design PROTAC MDM2 degrader[1].
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DC50058 VH032-C3-NH2((S,R,S)-AHPC-C3-NH2) Featured
(S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852. UNC6852 is an EED-targeted bivalent chemical degrader[1].
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DC50060 (S,R,S)-AHPC-C2-NH2 dihydrochloride Featured
(S,R,S)-AHPC-C2-NH2 dihydrochloride incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-OH can be used in the synthesis of a series of PROTACs[1].
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DC50062 Thalidomide-NH-PEG1-C2-NH2 Featured
Thalidomide-NH-PEG1-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
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DC50063 (S,R,S)-AHPC-C6-NH2 Featured
PROTAC building block.
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DC50065 (S,R,S)-AHPC-CO-CI-Br Featured
(S,R,S)-AHPC-CO-CI-Br is a novel protac building block,
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DC50068 (S,R,S)-AHPC-Me-C10-NH2 Featured
(S,R,S)-AHPC-Me-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432
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DC50069 (S,R,S)-AHPC-PEG4-NH2(E3 ligase Ligand-Linker Conjugates 7) Featured
(S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
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DC50070 (S,R,S)-AHPC-PEG2-NH2 (E3 ligase Ligand-Linker Conjugates 6 Free Base) Featured
(S,R,S)-AHPC-PEG2-NH2 (VH032-PEG2-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.
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DC50074 (S,R,S)-AHPC-Me-C1-NH2 Featured
(S,R,S)-AHPC-Me-C1-NH2 is a novel PROTAC Building block.
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DC50075 (S,R,S)-AHPC-Me-C2-NH2 Featured
(S,R,S)-AHPC-Me-C2-NH2 is a novel PROTAC building block.
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DC50076 (S,R,S)-AHPC-Me-C3-NH2 Featured
(S,R,S)-AHPC-Me-C3-NH2 is a novel PROTAC building block.
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DC50077 (S,R,S)-AHPC-Me-C4-NH2 Featured
(S,R,S)-AHPC-Me-C4-NH2 is a novel PROTACA building block.
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DC50078 (S,R,S)-AHPC-Me-C8-NH2 Featured
(S,R,S)-AHPC-Me-C8-NH2 is a novel PROTAC building block.
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DC50079 Thalidomide-O-amido-C5-NH2 Featured
Thalidomide-O-amido-C5-NH2 is a novel PROTAC building block.
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DC47886 Thalidomide-Piperazine 5-fluoride Featured
Thalidomide-Piperazine 5-fluoride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
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DC45710 Pomalidomide-amino-PEG5-NH2 hydrochloride Featured
Pomalidomide-amino-PEG5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
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DC45712 Pomalidomide-amino-PEG3-NH2 hydrochloride Featured
Pomalidomide-amino-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
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DC12141 E3 Ligase Ligand-Linker Conjugates 22 Featured
E3 Ligase Ligand-Linker Conjugates 22 incorporates an E3 ligase ligand and a linker, can be used for the treatment of EZH2-mediated cancer.
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DC46473 Lenalidomide-C9-aldehyde
Lenalidomide-C9-aldehyde is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide based cereblon ligand and a linker. Lenalidomide-C9-aldehyde can be used in the synthesis of a series of PROTACs, such as INY-03-041. INY-03-041 is a potent, highly selective and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2 and Akt3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively.
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DC29019 N3-PEG3-CH2CH2COOH
N3-PEG3-CH2CH2COOH a PEG-based PROTAC linker can be used in the synthesis of BI-3663, BI-4216 and BI-0319. Azido-PEG3-acid is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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DC42556 Thalidomide-NH-PEG4-COOH
Thalidomide-NH-PEG4-COOH is an E3 ligase ligand-linker conjugate which can be used for synthesizing dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP.
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DC46258 VHL Ligand-Linker Conjugates 17
VHL Ligand-Linker Conjugates 17 incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. VHL Ligand-Linker Conjugates 17 can be used in the synthesis of a series of PROTACs, such as ARD-266. ARD-266 is a highly potent androgen receptor (AR) PROTAC degrader.
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DC46474 Lenalidomide-PEG3-iodine
Lenalidomide-PEG3-iodine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide based cereblon ligand and a 3-unit PEG linker. Lenalidomide-PEG3-iodine can be used in the synthesis of a series of PROTACs, such as SJF620. SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM.
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DC46472 (S,R,S)-AHPC-C3-NH2 TFA
(S,R,S)-AHPC-C3-NH2 TFA (VH032-C3-NH2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852. UNC6852 is an EED-targeted bivalent chemical degrader.
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DC40422 Pomalidomide-amido-C1-Br
Pomalidomide-amido-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker. Pomalidomide-amido-C1-Br can be used to design a B-Raf PROTAC degrader PROTAC B-Raf degrader 1. PROTAC B-Raf degrader 1 has anti-cancer activity.
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