Home > Inhibitors & Agonists > Tyrosine Kinase > Syk
Cat. No. Product name CAS No.
DC9632 BAY 61-3606 (dihydrochloride) Featured

BAY 61-3606 2Hcl is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.

648903-57-5
DC10660 BAY 61-3606 free base Featured

BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.

732983-37-8
DC7948 PRT-060318(PRT318) Featured

PRT-060318 is a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model.

1194961-19-7
DC1014 R406 free base Featured

R406 is a potent Syk inhibitor with IC50 of 41 nM and also potently inhibits Flt3.

841290-80-0
DC8733 R406 Featured

R406 is a potent Syk inhibitor with IC50 of 41 nM and also potently inhibits Flt3.

841290-81-1
DC9841 Fostamatinib(R788) Featured

R788 (Fostamatinib), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.

901119-35-5
DC1013 R788 disodium (Fostamatinib) Featured

R935788 (Fostamatinib disodium, R788) is a Syk inhibitor with IC50 of 41 nM.

1025687-58-4
DC9759 RO0921 Featured

RO0921 is a novel, potent SYK inhibitor.

1446790-62-0
DC10523 TAK-659 HCl Featured

TAK-659 hydrochloride is a potent, selective and orally available spleen tyrosine kinase (Syk) inhibitor with an IC50 of 3.2 nM.

1952251-28-3
DC28254 Lanraplenib monosuccinate

Lanraplenib monosuccinate (GS-9876 monosuccinate) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib monosuccinate (GS-9876 monosuccinate) inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans.

1800046-97-2
DC28255 Lanraplenib succinate

Lanraplenib succinate (GS-9876 succinate) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib succinate (GS-9876 succinate) inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans.

1800047-00-0
DC40367 Syk-IN-1

Syk-IN-1 (compound 4) is a potent Syk inhibitor, with an IC50 of 35 nM.

1491150-77-6
DC40848 SRX3207 Featured

SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor. SRX3207 possesses anti-tumor activity.

2254693-15-5
DC41092 Cerdulatinib hydrochloride

Cerdulatinib hydrochloride (PRT062070) is a selective, oral active and reversible ATP-competitive inhibitor of dual SYK and JAK, with IC50s of 32 nM, 0.5 nM, 12 nM, 6 nM and 8 nM for SYK and Tyk2, JAK1, 2, 3, respectively. Cerdulatinib hydrochloride could be used to research autoimmune disease and B-cell malignancies.

1369761-01-2
DC42006 Syk Kinase Peptide Substrate, Biotin labeled

Syk Kinase Peptide Substrate, Biotin labeled is a biotin-labled Syk kinase peptide substrate.

DC42007 Syk Kinase Peptide Substrate

Syk Kinase Peptide Substrate is a Syk kinase peptide substrate.

865778-47-8
DC42425 Syk-IN-4

Syk-IN-4 is a potent, selective and orally bioavailable SYK with an IC50 of 0.31 nM. SYK has emerged as a potential target for autoimmunity and hematological cancers.

DC48025 Cevidoplenib dimesylate

Cevidoplenib is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities.

2043659-93-2
DC48364 Sovleplenib

Sovleplenib is a potent spleen tyrosine kinase (Syk) inhibitor, extracted from patent WO2012167733 A1.

1415792-84-5
DC48946 SYK/JAK-IN-1

SYK/JAK-IN-1 is dual SYK/JAK inhibitor with IC50s of <5 nM for SYK and JAK2, respectively.

2737326-28-0
DC70447 GSK143

GSK143 is a highly potent, selective, orally efficacious Syk inhibitor with pIC50 of 7.5, >600-fold selective over ZAP-70; inhibits anti-IgM induced Erk1/2 phosphorylation in Ramos cells with pIC50 of 7.1, and anti-IgM induced CD69 surface expression in primary B cells with pIC50 of 6.6; shows good efficacy in the rat Arthus model.

1240390-27-5
DC70457 GSK2646264

GSK2646264 (GSK-2646264) is a potent, selective Spleen Tyrosine Kinase (Syk) inhibitor with pIC50 of 7.1, >300-fold selectivity over Autota B; inhibits anti-IgM induced Erk1/2 phosphorylation in Ramos B cells with pIC50 of 6.7.

1398695-47-0
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