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Home > Inhibitors & Agonists > Cell Cycle/DNA Damage > Telomerase

Telomerase

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Cat. No. Product Name Field of Application Chemical Structure
DC73228 Teloxantron
Teloxantron (Telomerase inhibitor TXT4) is a potent small molecule inhibitor of telomerase activity with IC50 of 9.61 uM, 7-fold lower than BIBR1532 (Cat# PC-45170), inhibits the processivity of telomerase with preferential DNA damage on telomeres.
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DC73227 DIZ-3
DIZ-3 is a dimeric aryl-substituted imidazole as a selective multimeric G-quadruplex (G4) ligand, intercalates into the G4-G4 interface, induces cell cycle arrest and apoptosis, and inhibits cell proliferation in alternative lengthening of telomere (ALT)
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DC8861 2'-Deoxythioguanosine Featured
6-thio-dG is a nucleoside analog and telomerase substrate.
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DC29105 Epithalon Featured
Epitalon is an anti-aging agent and a telomerase activator. Epitalon has an inhibitory effect of the on the development of spontaneous tumors in mice, has geroprotective actions and intranasal administration increases neuronal activity. Epitalon can be used for cancer, old age and Retinitis Pigmentosa.
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DC72320 L2H2-6OTD
L2H2-6OTD, containing one to four G-quadruplex binding loops, is a telomeric inhibitor analogue. l2H2-6OTD has telomerase inhibitory activity with an IC50 value of 15 nM.
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DC7085 BIBR-1532 Featured
BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM.
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DC11446 Cycloastragenol Featured
Cycloastragenol, the aglycone derivative of astragaloside A, can be found in various species of Astragalus and is reported to activate telomerase.
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DC11310 MST312 Featured
MST312 is a telomerase inhibitor (IC50 = 0.67 μM in a TRAP assay).
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DC41078 Telomestatin
Telomestatin is a very potent telomerase inhibitor and can be isolated from Streptomyces anulatus 3533-SV4. Telomestatin selectively facilitates the formation of intramolecular G-quadruplexes, in particular, that produced from the human telomeric sequence d[T2AG3]4. Telomestatin is an ADC cytotoxin and can be used for cancer research.
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DC29106 Epithalon TFA
Epitalon TFA is an anti-aging agent and a telomerase activator. Epitalon TFA has an inhibitory effect of the on the development of spontaneous tumors in mice, has geroprotective actions and intranasal administration increases neuronal activity. Epitalon TFA can be used for cancer, old age and Retinitis Pigmentosa.
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