DSPE-PEG-Mannose,1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(polyethyleneglycol)-Mannose (sodium salt)is white solid for drug delivery systems, It is an active target material, Itcan be used as an antitumor drug carrier and active targeted delivery

TAMRA-PEG4-NHS ester is a TAMRA red fluorescent dye derivative containing an NHS ester group which can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

DSPE-PEG-TCO (2000 Da) is a functionalized polyethylene glycol lipid conjugate engineered to enhance drug delivery systems. This amphiphilic polymer-lipid hybrid demonstrates unique capabilities in optimizing the bioavailability and targeted distribution of hydrophobic therapeutic compounds. Its molecular architecture combines a lipid anchor with a biocompatible PEG chain terminated by a trans-cyclooctene (TCO) group, enabling precise tissue-specific interactions while improving pharmacokinetic profiles. Researchers frequently employ this advanced biomaterial in developing nanoparticle formulations and ligand-directed therapeutic platforms for enhanced precision medicine applications.

The transferrin receptor (TfR) is a transmembrane glycoprotein whose function is to mediate iron absorption through its interaction with transferrin. In normal cells, the expression level of the receptor is low, and the expression of the transferrin receptor in cells (chronic lymphocytic non-Hodgkin tumors) is significantly increased due to the increased demand for iron in rapidly growing cells [2-4]. At present, two transferrin receptors, TfR1 and TfR2, have been found, both of which are type II transmembrane glycoproteins that bind to transferrin and mediate iron absorption. TfR1 is expressed in many cells (such as red blood cells, hepatocytes, monocytes), and can change its conformation according to the change of environmental pH, and convert the results of conformational change into a change in the binding strength of transferrin. TfR2 is mainly expressed in the liver, and its main function may be to regulate and maintain the homeostasis of iron ions in the body, while its role in transporting iron ions to rapidly dividing tissues is weak. Using the effective targeting function of transferrin receptor, the cross-linking of transferrin and drugs can improve the specific binding ability of drugs, but also improve the effect.

Glucose, organic compound, molecular formula C6H12O6. It is one of the most widely distributed and important monosaccharides in nature, and it is a polyhydroxyaldehyde. Glucose plays an important role in the field of biology, that is, the main energy supplier of living things. Plants produce glucose through photosynthesis. Liposome has the advantages of low toxicity, easy preparation, as a carrier of both water-soluble and fat-soluble drugs, suitable for a variety of drug delivery routes, improve drug stability, and achieve targeted drug delivery. However, after the liposome enters the body, it is easy to be taken up and cleared by RES cells due to the specific conditioning effect of opsonins in plasma on the liposome and the non-specific hydrophobic interaction between RES cells and liposome.

DSPE-PEG(2000)-amine is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE (DSPE; Item No. 15095). It has been used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents. DSPE-PEG(2000)-amine has also been used in the synthesis of fluorescein isothiocyanate-loaded mesoporous silica nanoparticles for imaging applications.4 It can be conjugated to a variety of functional molecules for improved cellular targeting and uptake of DSPE-PEG(2000)-amine-containing nanoparticles.

DSPE-PEG2K-triGalNAc is a polar lipid composed of DSPE and tri-N-acetylgalactosamine that can be used to construct liposomes target to asialoglycoprotein receptor (ASGPR).

DSPE-PEG-Maleimide, MW 2,000 is a PEG compound with DSPE and maleimide groups. The DSPE-PEGs have been FDA approved for medical applications. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The hydrophilic polyPEG increases the water solubility of the overall compound allowing for the delivery of the drug. Maleimide groups can react with thiol groups between pH 6.5 to 7.5.

DSPE-Hyd-PEG, also known as distearoylphosphoethanolamine-hydrazide-polyethylene glycol, is a type of lipid-based polymer that has various applications in drug delivery and biomedical research. One of the main applications of DSPE-Hyd-PEG is in the field of targeted drug delivery. It is often used as a component of liposomes or lipid nanoparticles to improve the stability and targeting ability of drug carriers. DSPE-Hyd-PEG can be conjugated with targeting ligands, such as antibodies or peptides, to specifically bind to receptors on the surface of target cells. This targeted drug delivery system allows for more efficient and selective delivery of therapeutic agents to the desired site, while minimizing off-target effects.

DSPE-PEG-Biotin (MW 1000) is a PEG-based PROTAC linker

The phospholipid polyethylene glycol alkyne (DSPE PEG Alkyne) can be used to modify proteins, peptides and other materials or small molecules. Alkynyl (- ALK) can react with copper catalyzed azide in aqueous solution. 2-Distearoyl-sn-Glycero-3-Phosphoethanolamine (DSPE) conjugated polyethylene glycol is a combination of phospholipid and polyethylene glycol with hydrophilicity and hydrophobicity. Polyethylene glycol phospholipid liposomes form high-quality materials, which can be used for drug delivery, gene transfection and vaccine delivery. PEGylated phospholipid can significantly improve blood circulation time and stabilize drug encapsulation. These materials can also be used for targeted drug delivery by modifying ligands with target surfaces such as antibodies and peptides.

DSPE-m-PEG-NHS (MW 3400) is a pegylated phospholipid derivatives which can be used to prepare liposome or lipid nanoparticles for targeted drug delivery system, such as DNA or mRNA vaccine.

DSPE-Hyd-PEG, also known as distearoylphosphoethanolamine-hydrazide-polyethylene glycol, is a type of lipid-based polymer that has various applications in drug delivery and biomedical research. One of the main applications of DSPE-Hyd-PEG is in the field of targeted drug delivery. It is often used as a component of liposomes or lipid nanoparticles to improve the stability and targeting ability of drug carriers. DSPE-Hyd-PEG can be conjugated with targeting ligands, such as antibodies or peptides, to specifically bind to receptors on the surface of target cells. This targeted drug delivery system allows for more efficient and selective delivery of therapeutic agents to the desired site, while minimizing off-target effects.

DSPE-PEG-MAL is one of the reactive phospholipid PEG reagents that can react with sulfhydryl group (mercaptan, -SH). DSPE (1, 2-distearyl-Sn-glycerol 3-phosphate ethanolamine) is a highly hydrophobic saturated 18C phospholipid.

The molecules can be labeled in the aqueous phase without organic solvents. Therefore, the product is especially suitable for labeling proteins that are easily denatured in the organic phase and proteins with low solubility. Polyethylene glycol phospholipid liposomes form high-quality materials, which can be used for drug delivery, gene transfection and vaccine delivery. Pegylated phospholipids can significantly improve blood circulation time and stabilize drug encapsulation. These materials can also be used for targeted drug delivery by modifying surface ligands such as antibodies and peptides. (DSPE) conjugated polyethylene glycol is a combination of phospholipids and polyethylene glycol, which has hydrophilicity and hydrophobicity. These materials can also be used for targeted drug delivery by modifying ligands with target surfaces, such as antibodies and peptides. Cyanogen dye cyanine is often used in biomolecular labeling, fluorescence imaging and other fluorescent biological analysis. Cy5 (sulfo-cyanine5) is a reactive dye used to label amino groups of peptides, proteins and oligonucleotides. Excitation wavelength (nm): 649, emission wavelength (nm): 670.

The streptavidin molecule consists of four identical peptide chains, and the contents of glycine and alanine are relatively large in the amino acid composition, and the active group binding biotin is also the tryptophan residue in the peptide chain. Streptavidin is a slightly acidic (pH6.0) protein and does not carry any sugar groups. Under the action of proteolytic enzyme, streptavidin can be broken between N-terminal 10 ~ 12 and C-terminal 19 ~ 21, and the formed core streptavidin still maintains the complete ability to bind biotin. The activity unit of streptavidin is also expressed in terms of the amount required to bind 1μg biotin, and the high activity of 1mg streptavidin can reach 18U. streptavidin (SA) is a protein secreted by streptomyces avidinii with a molecular weight of 65kD. Streptavidin molecules are composed of four identical peptide chains, each of which can bind a biotin without any sugar group, so like avidin, one streptavidin molecule can also bind four biotin molecules, and the affinity constant (K) of both is 1015mol/L. Streptavidin is more widely applicable than avidin.

DSPE-PEG(2000)-Amine is used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents.

DSPE-PEG-SH, MW 2000 is a pegylated phospholipid with thiol group which is reactive with maleimide to form a covalent thioether linkage. The amphiphatic polymer can form lipid bilayer in aqueous solution and be used to encapsulate agents for drug delivery system, such as mRNA vaccine.

DSPE-PEG-CLS is a phospholipid PEG derivative used in liposome preparation, phospholipid polyethylene glycol binding with hydrophilic and hydrophobic, polyethylene glycol phospholipid liposome formation material, which can be used for drug delivery, gene transfection and vaccine delivery. Cholesterol is the basic substance of cell membrane and liposome, is also an indispensable important substance of animal tissue cells, it not only participates in the formation of cell membrane, but also is the raw material of synthesis of bile acid, vitamin D and steroid hormone.

The affinity between lactoferrin and iron ion is very high, which is 250 to 300 times that of transferrin. According to the difference of lactoferrin binding iron ions, it can be divided into three types: iron deficiency type, iron semi-satiation type and iron saturated type. Different types of lactoferrin have different ability to resist pasteurization thermal denaturation, in which iron saturated type resistance is strong, iron deficiency type resistance is weak. Lactoferrin can bind not only Fe3+ and Fe2+, but also Cu2+, Mn2+ and Zn2+.

DSPE-Hyd-PEG, also known as distearoylphosphoethanolamine-hydrazide-polyethylene glycol, is a type of lipid-based polymer that has various applications in drug delivery and biomedical research. One of the main applications of DSPE-Hyd-PEG is in the field of targeted drug delivery. It is often used as a component of liposomes or lipid nanoparticles to improve the stability and targeting ability of drug carriers. DSPE-Hyd-PEG can be conjugated with targeting ligands, such as antibodies or peptides, to specifically bind to receptors on the surface of target cells. This targeted drug delivery system allows for more efficient and selective delivery of therapeutic agents to the desired site, while minimizing off-target effects.

DSPE-Hyd-PEG, also known as distearoylphosphoethanolamine-hydrazide-polyethylene glycol, is a type of lipid-based polymer that has various applications in drug delivery and biomedical research. One of the main applications of DSPE-Hyd-PEG is in the field of targeted drug delivery. It is often used as a component of liposomes or lipid nanoparticles to improve the stability and targeting ability of drug carriers. DSPE-Hyd-PEG can be conjugated with targeting ligands, such as antibodies or peptides, to specifically bind to receptors on the surface of target cells. This targeted drug delivery system allows for more efficient and selective delivery of therapeutic agents to the desired site, while minimizing off-target effects.

DSPE-Hyd-PEG, also known as distearoylphosphoethanolamine-hydrazide-polyethylene glycol, is a type of lipid-based polymer that has various applications in drug delivery and biomedical research. One of the main applications of DSPE-Hyd-PEG is in the field of targeted drug delivery. It is often used as a component of liposomes or lipid nanoparticles to improve the stability and targeting ability of drug carriers. DSPE-Hyd-PEG can be conjugated with targeting ligands, such as antibodies or peptides, to specifically bind to receptors on the surface of target cells. This targeted drug delivery system allows for more efficient and selective delivery of therapeutic agents to the desired site, while minimizing off-target effects.

Phospholipids are commonly used polymeric gene carriers. DSPE with high molecular weight can effectively compound DNA, and has strong buffered capacity under endosomal pH conditions, showing good transfection efficiency for a variety of cells. However,DAPE is not easily degraded, and high molecular weight DAPE as a gene carrier may lead to short - or long-term cytotoxicity.

Long circulating liposomes were obtained by modifying the surface of liposomes with polyethylene glycol, which could prolong the half-life of liposomes, improve its stability in blood circulation, and change the biological distribution of liposomes.

DSPE-PEG-FITC is a fluorescein attached PEG lipid. It can be used to prepare liposomes as drug carrier in targeted drug delivery. The polymer is modified with fluorescein (green) dye which can be used for staining cells, tissues, biomarkers, or nanoparticles.