Cat. No. | Product Name | Field of Application | Chemical Structure |
---|---|---|---|
DC8780 | Flavopiridol Hydrochloride Featured |
Flavopiridol hydrochloride is a potent pan-cyclin-dependent kinase (CDK) inhibitor with a unique ATP-competitive mechanism.
More description
|
![]() |
DC5072 | Duvelisib (IPI-145, INK1197) Featured |
Duvelisib (IPI-145) is a selective inhibitor of the p110δ isoform, exhibiting IC50 values of 2.5 nM, 27.4 nM, 85 nM, and 1602 nM for p110δ, p110γ, p110β, and p110α, respectively, highlighting its specificity and potency.
More description
|
![]() |
DC11370 | TAK-901 Featured |
TAK-901 is a non-selective Aurora kinase inhibitor (IC50s = 3.1, 10, and 4.2 nM for Aurora A, B, and C, respectively).
More description
|
![]() |
DC1084 | ZM447439 (ZM-447439) Featured |
ZM-447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively.
More description
|
![]() |
DC8840 | CB-5083 Featured |
CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models .
More description
|
![]() |
DC7367 | AZ-960 Featured |
AZ 960 is a novel ATP competitive JAK2 inhibitor with IC50 and Ki of <3 nM and 0.45 nM, 3-fold selectivity of AZ960 for JAK2 over JAK3.
More description
|
![]() |
DC11726 | Milademetan Featured |
Milademetan (DS-3032) is a specific and orally active MDM2 inhibitor for the research of acute myeloid leukemia (AML) or solid tumors. Milademetan (DS-3032) induces G1 cell cycle arrest, senescence and apoptosis.
More description
|
![]() |
DC5027 | ABC294640(Opaganib) Featured |
ABC294640 is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity.
More description
|
![]() |
DC8275 | Apilimod Featured |
Apilimod(STA 5326) is a potent IL-12/IL-23 inhibitor, IL-12 production in cultures of IFN-r/LPS–stimulated human PBMCs is strongly inhibited by STA-5326 with an IC50 of 10 nM.
More description
|
![]() |
DC8051 | AG-120 (Ivosidenib) Featured |
AG-120 is a first-in-class, orally available, selective, potent inhibitor of the mutated IDH1 protein.
More description
|
![]() |
DC8164 | Gilteritinib(ASP2215) Featured |
FLT3/AXL inhibitor
More description
|
![]() |
DC4127 | ABT-263 (Navitoclax) Featured |
ABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤ 1 nM, respectively.
More description
|
![]() |
DC8377 | CC-115 Featured |
CC-115 is a dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR), with potential antineoplastic activity.
More description
|
![]() |
DC5147 | Molibresib (I-BET-762) Featured |
GSK 525762A is a potent small molecule inhibitors that disrupt the function of the BET family of bromodomains (Brd2, Brd3, and Brd4).
More description
|
![]() |
DC2014 | Flavopiridol Featured |
Flavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM, and CDK7 with IC50 of 300 nM.
More description
|
![]() |
DC7114 | Dinaciclib (SCH727965) Featured |
Dinaciclib (SCH727965) is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM, respectively.
More description
|
![]() |
DC7486 | PX-478 2HCL Featured |
PX-478 is an inhibitor of HIF-1a with an IC50 of 20-30μM enhances radiosensitivity of prostate carcinoma cells.
More description
|
![]() |
DC9837 | Larotrectinib (LOXO-101 sulfate) Featured |
LOXO-101 is a small molecule that was designed to block the ATP binding site of the TRK family of receptors, with 2 to 20 nM cellular potency against the TRKA, TRKB, and TRKC kinases.
More description
|
![]() |
DC7359 | Asp-3026 Featured |
ASP3026 is a novel and selective inhibitor for ALK with IC50 of 3.5 nM.
More description
|
![]() |
DC5176 | Pevonedistat Featured |
MLN4924 is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with IC50 of 4 nM.
More description
|
![]() |
DC8541 | ORY-1001(Ladademstat) Featured |
ORY-1001 dihydrochloride (RG-6016, Ladademstat) is a highly potent, selective inhibitor of lysine-specific demethylase KDM1A (LSD1) with IC50 of 18 nM, displays high selectivity for KDM1A over other FAD-containing monoamine oxidases.
More description
|
![]() |
DC9755 | eFT508(Tomivosertib) Featured |
Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. Tomivosertib (eFT-508) inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance.
More description
|
![]() |
DC4181 | Imatinib mesylate Featured |
Imatinib Mesylate is orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively.
More description
|
![]() |
DC4119 | YM155 Featured |
YM155 is a potent IAP (inhibitor of apoptosis proteins) inhibitor for survivin with IC50 of 0.54 nM.
More description
|
![]() |
DC8252 | Vorinostat (SAHA) Featured |
Vorinostat (SAHA) is an HDAC1/3 inhibitor with IC50 of ~10 nM.
More description
|
![]() |
DC7187 | Volasertib(BI6727) Featured |
Volasertib(BI6727) is a highly potent PLK1 inhibitor with an IC50 of 0.87 nM; shows 6- and 65-fold greater selectivity against Plk2 and Plk3.
More description
|
![]() |
DC9701 | Tipifarnib Featured |
Tipifarnib (IND 58359; R115777) is a potent and specific farnesyltransferase inhibitor with an IC50 of 0.6 nM.
More description
|
![]() |
DC7506 | Sotrastaurin Featured |
Sotrastaurin(AEB-071) is a potent and selective pan-PKC inhibitor, mostly for PKCθ with Ki of 0.22 nM; inactive to PKCζ.
More description
|
![]() |
DC7297 | SNS-032(BMS-387032) Featured |
SNS-032(BMS-387032) is a potent inhibitor of cyclin-dependent kinases (cdks) 9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively).
More description
|
![]() |
DC5024 | MK-8776 (SCH 900776) Featured |
SCH 900776 is a selective Chk1 inhibitor with IC50 of 3 nM. It shows 50-fold selectivity against Chk2. Phase 2.
More description
|
![]() |