Home > Inhibitors & Agonists > Wnt/Notch/Hedgehog > GSK-3
Cat. No. Product name CAS No.
DC5144 1-Azakenpaullone

1-Azakenpaullone is a potent and ATP-competitive GSK-3β (glycogen synthase kinase-3β) inhibitor (IC₅₀ = 18 nM).

676596-65-9
DC11827 9-ING-41 Featured

9-ING-41 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor[1]. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK-3β. 9-ING-41 has anticancer activity[2].

1034895-42-5
DC11299 ABC 1183

ABC1183 is a selective dual GSK3α/β and CKD9 inhibitor.

1042735-18-1
DC8263 Bikinin Featured

Bikinin is a strong activator of brassinosteroid (BR) signaling.

188011-69-0
DC7663 BIO Featured

BIO (6-bromoindirubin-3'-oxime) is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β, shows >16-fold selectivity over CDK5, also a pan-JAKinhibitor.

667463-62-9
DC7384 CHIR-98014 Featured

CHIR-98014 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.

252935-94-7
DC9703 CHIR-99021 HCl Featured

CHIR-99021 HCl is a glycogen synthase kinase 3 beta inhibitor that has antiproliferative activity in vitro and in vivo.

1797989-42-4
DC1023 CHIR-99021 (CT99021) Featured

CHIR-99021 is a glycogen synthase kinase 3 beta inhibitor that has antiproliferative activity in vitro and in vivo.

252917-06-9
DC9726 CP21 (CP21R7) Featured

CP21R7 is a potent and selective GSK-3β inhibitor.

125314-13-8
DC4227 SB216763 Featured

SB 216763 is a potent and selective cell permeable ATP-competitive inhibitor of GSK3α with an IC50 value of 34 nM (similar potency for GSK3β).

280744-09-4
DC2067 TDZD-8 Featured

TDZD-8 is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM.

327036-89-5
DC7680 IM-12 Featured

The GSK3β Inhibitor XIX, IM-12 is a selective GSK-3β inhibitor with IC50 of 53 nM, and also enhances canonical Wnt signalling.

1129669-05-1
DC1063 TWS119 Featured

TWS119 is a GSK-3β inhibitor with IC50 of 30 nM.

601514-19-6
DC7004 AR-A014418(GSK3β Inhibitor VIII) Featured

AR-A014418 is a selective and effective GSK3β inhibitor with an IC 50 value of 104 +/- 27 nM; no significant inhibition on 26 other kinases.

487021-52-3
DC28275 BIP-135

BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect.

941575-71-9
DC28365 (Rac)-BRD0705

(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML).

1597440-03-3
DC28691 GSK-3β inhibitor 2

GSK-3β inhibitor 2 (Compound 3) is a potent, selective and orally active GSK-3β inhibitor with an IC50 of 1.1 nM. GSK-3β inhibitor 2 can cross the blood-brain barrier. GSK-3β inhibitor 2 has the potential for Alzheimer's disease.

1702428-31-6
DC40331 BRD3731

BRD3731 is a selective GSK3β inhibitor, with IC50s of 15 nM and 215 nM for GSK3β and GSK3α, respectively. BRD3731 can be used for the research of a mood disorder, post-traumatic stress disorder (PTSD), psychiatric disorder, diabetes, and neurodegenerative disorder.

2056262-07-6
DC40570 KY19382 Featured

KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β, with IC50s of 19 and 10 nM, respectively. KY19382 activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3β activity. KY19382 can be used for the research of high fat diet (HFD) induced metabolic diseases.

2226664-93-1
DC41037 SAR502250

SAR502250 is a potent, selective, ATP competitive, orally active and brain-penetrant inhibitor of GSK3, with an IC50 of 12 nM for human GSK-3β. SAR502250 displays antidepressant-like activity. SAR502250 can be used for the research of Alzheimer’s disease (AD).

503860-57-9
DC41591 Phospho-Glycogen Synthase Peptide-2(substrate)

Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate?for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases.

851366-97-7
DC41592 Phospho-Glycogen Synthase Peptide-2(substrate) TFA

Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate?for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases.

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