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Cat. No. Product name CAS No.
DC11772 AZD-4316

A potent respiratory syncytial virus (RSV) fusion inhibitor..

1243324-08-4
DC11647 JNJ-2408068

A potent RSV fusion inhibitor with EC50 of 0.16 nM against some lab strains.

317846-22-3
DC11770 PC786

PC786 (PC-786) is a potent non-nucleoside RSV L-protein polymerase inhibitor with IC50 of 2.1 nM and 0.5 nM in cell-free enzyme assay and mini-genome assay in HEp-2 cells, respectively.

1902114-15-1
DC10006 RSV-604 Featured

RSV604 is a novel inhibitor of respiratory syncytial virus replication(EC50=0.86 uM); a putative RSV nucleoprotein(N) inhibitor in phase 2 clinical trials.

676128-63-5
DC51000 Sisunatovir (Synonyms: RV521) Featured

Sisunatovir (RV521), an orally available inhibitor of the RSV fusion (RSV-F) protein, exhibits potent efficacy against a panel of clinical isolates of RSV-A and RSV-B viruses, with IC50s of 1.4 nM and 1.0 nM, respectively.

1903763-82-5
DC51001 Sisunatovir HCl Featured

Sisunatovir, also known as RV521, is a highly potent fusion inhibitor with efficacy against a panel of clinical isolates of RSV-A and RSV-B viruses. RV521 exhibited a mean IC50 of 1.2 nM against a panel of RSV A and B laboratory strains and clinical isolates with antiviral efficacy in the Balb/C mouse model of RSV infection. Oral bioavailability in preclinical species ranged from 42 to >100% with evidence of highly efficient penetration into lung tissue. In healthy adult human volunteers experimentally infected with RSV, a potent antiviral effect was observed with a significant reduction in viral load and symptoms compared to placebo.

1903763-83-6
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