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Cat. No. Product name CAS No.
DC11206 HSD-016 Featured

HSD-016 (HSD016) is a potent, selective, and efficacious 11β-HSD1 inhibitor with IC50 of 149 and 530 nM for mouse and human 11β-HSD1, respectively.

DC11207 INCB13739 Featured

INCB13739 (INCB-13739) is a potent, selective, oral 11βHSD1 inhibitor (IC50=1.1 nM) with high seelctivity over other dehydrogenases, glucocorticoid and mineralocorticoid receptors..

DC11522 Imarikiren hydrochloride

A highly potent, selective, orally active renin inhibitor with IC50 of 2.1 nM in hPRA assay.

DC11933 RX 871024

A imidazoline compound that stimulate insulin release by inhibition of ATP-dependent K+ channels and inducing of Ca2+ mobilization in mouse pancreatic beta-cells.

DC11536 Imigliptin dihydrochloride

A novel potent, selective, orally available DPP-4 inhibitor with IC50 of 9 nM.

DC11898 Gosogliptin

A potent, selective, competitive, orally active dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 13 nM.

DC11899 Gosogliptin dihydrochloride

A potent, selective, competitive, orally active dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 13 nM.

DC7045 A-769662 Featured

A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM, little effect on GPPase/FBPase activity.

DCAPI1034 Alendronate (Fosamax)

Alendronate (Fosamax)

DC9830 AM-2394 Featured

AM-2394 is a potent and selective Glucokinase agonist (GKA), which catalyzes the phosphorylation of glucose to glucose-6-phosphate.

DC11809 APX-115 Featured

APX-115 (Ewha 18278) is a first-in-class, orally active, pan-NADPH oxidase (Nox) inhibitor with Ki of 1.08, 0.57, 0.63 nM for Nox1, Nox2, and Nox4, respectively.

DC11174 ASP7657 Featured

ASP7657 (ASP-7657) is a potent, selective, orally active prostaglandin EP4 receptor antagonist with Ki values of 6.02 nM and 2.21 nM for rat and human EP4 receptors, resepctively.

DC11032 AZD9977 Featured

AZD9977 is a first-in-class, potent, selective, mineralocorticoid receptor (MR) modulator with IC50 of 0.37. 0.08 and 0.08 uM for human, mouse and rat MR, respectively.

DC8160 ZGN-440(Beloranib)

Beloranib is being studied as a first-in-class obesity therapy that demonstrates a unique mechanism of action through methionine aminopeptidase 2 (MetAP2 ) inhibition.

DC8186 Bexagliflozin(THR1442,EGT1442)| Featured

Bexagliflozin is a potent and selective SGLT2 inhibitor with IC50 value of 5.6 μM /2 nM in SGLT1 /SGLT2 respectively.

DC8571 BGP-15 Featured

BGP-15 is a PARP inhibitor and insulin sensitizer.

DC11842 BI 135585

BI 135585 (BI-135585, BI135585) is a potent, selective, orally active 11β-HSD1 inhibitor with IC50 of 4.3 nM and 53 nM in human adipocytes and primary human adipose tissue, respectively.

DC11761 BMS-816336

A novel potent, selective, orally active human 11β-HSD1 inhibitor with IC50 of 3.0 nM.

DC8392 BQ-123 Featured

BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.

DC8089 BVT 2733(BVT.2733) Featured

BVT 2733 is a selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor,protecting osteoblasts against endogenous glucocorticoid induced dysfunction.

DC8278 BVT-14225

BVT 14225 is a new selective 11b-HSD1 inhibitor, it belongs to a class of arylsulfonamidothiazoles with in vitro and in vivo antidiabetic effects

DCAPI1559 Calcifediol Featured

Calcifediol is a major circulating metabolite of vitamin D3, acting as a competitive inhibitor with an apparent Ki of 3.9 μM, suppresses PTH secretion and mRNA (ED50=2 nM).

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