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ULK

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Cat. No. Product Name Field of Application Chemical Structure
DC70343 DCC-3116 Featured
DCC-3116 (DCC3116) is a first-in-class, selective inhibitor of ULK1/2 kinases (IC50=4.7/35 nM) and autophagy.DCC-3116 is an oral ULK1/2 inhibitor targeting the autophagy pathway, a key mechanism of tumor survival and resistance to targeted therapy.
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DC74587 XST-14
XST-14 is a potent, competitive, and highly selective inhibitor of ULK1 and exhibits an IC50 of 26.6 nM in an in vitro ULK1 kinase activity assay, respectively. XST-14 reduces the phosphorylation of the ULK1 downstream substrate and induces autophagy inhibition. It exhibits antitumor effects.
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DC73150 MR-2088
MR-2088 is a potent and selective ULK1/2 inhibitor with IC50 of 2.0 nM and MST Kd value of 1.5-4.4 nM (ULK1), efficiently inhibits autophagy.
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DC9702 MRT68921 Featured
MRT68921 is the most potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively.
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DC8316 SBI-0206965 Featured
SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor.
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DC10635 MRT67307 HCl Featured
MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively.
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DC10715 LYN-1604 Featured
LYN-1604 is a potential ULK1 agonist with IC50 of 1.66 μM against MDA-MB-231 cells and it binds to wild-type ULK1 with a binding affinity in the nanomole range (Kd=291.4 nM).
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DC11604 SR-20295
SR-20295 (SR20295) is a novel potent ULK1 inhibitor with IC50 of 45 nM..
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DC11603 SR-19871
A novel potent ULK1 inhibitor with IC50 of 11 nM..
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