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Home > Inhibitors & Agonists > Wnt/Notch/Hedgehog > Dishevelled

Dishevelled

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Cat. No. Product Name Field of Application Chemical Structure
DC74451 NPL-4011
NPL-4011 is a specific small molecule inhibitor of PDZ domain of human Dvl1 (Dvl1-PDZ) with KD vaule of 34.5 uM in NMR titration experiments.
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DC74450 BMD4722
BMD4722 is a highly potent, small-molecule inhibitor of Dvl-CXXC5 interaction with IC50 of 2.59 uM, directly binds to the Dvl PDZ domain (Kd=22.3 uM).
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DC74449 BMD4702
BMD4702 is a small molecule Dishevelled (Dvl) PDZ domain with binding Kd of 186 nM.
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DC70553 KY19334
KY19334 is a specific small molecule inhibitor of CXXC5-Dishevelled (Dvl) protein-protein interaction (PPI), restores the Wnt/β‐catenin signalling.KY19334 reverses obesity‐related metabolic diseases with adult tissue remodelling.Oral administration of KY19334 (25 mg/kg) suppressed fasting glucose levels improves obesity‐related insulin resistance with long‐lasting effect in HFD‐fed mice.KY19334 treatment improves hepatic glucose homeostasis. KY19334 enhances energy expenditure by increasing the thermogenic activity of beige‐fat tissues.KY19334 treatment restores β‐cell mass and functions in HFD‐fed and STZ‐induced diabetes mellitus (DM) mice.
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DC11327 NSC 668036
NSC 668036 is an inhibitor of the Dishevelled (Dvl) protein PDZ domain (Kd = 240 μM for mouse Dvl1 PDZ domain).
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