Home > Inhibitors & Agonists > Wnt/Notch/Hedgehog > Beta-catenin
Cat. No. Product name CAS No.
DCL-046 Triptolide,14-deoxy-14-oxo

>98%,Standard References

DCS-054 Carnosic acid

>98%,Standard References

DC10976 E-7386

E-7386 (E7386) is a potent, orally active modulator of CBP/beta-catenin, disrupts the interaction and inhibits canonical Wnt signaling pathway /TCF reporter gene activity in LiCl-stimulated HEK-293 and MDA-MB-231 with IC50 of 55 and 73 nM, respectively.

DC7414 FH535 Featured

FH535 is a compound that suppresses both Wnt/beta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling.

DC3130 ICG-001 Featured

ICG-001 is a small-molecule antagonist of b-catenin/TCF-mediated transcription (IC50 = 3 uM) and specifically downregulates the expression of a subset of b-catenin/TCF-responsive genes. ICG-001 binds specifically to cyclic AMP response element-binding pro

DC10680 iCRT3 Featured

iCRT3 is an inhibitor of both Wnt and β-catenin-responsive transcription.

DC9952 IQ-1 Featured

IQ-1 has many functions such as decreasing Wnt-stimulated phosphorylation, maintaining the pluripotency of murine ESCs, preventing PP2A/Nkd interaction and so on.

DC10556 KY1220 Featured

KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC50 of 2.1 μM in HEK293 reporter cells.

DC9880 KYA1797K Featured

KYA1797K is a highly potent and selective Wnt/β-catenin inhibitor with IC50 of 0.75 µM (TOPflash assay).

DC12384 LF3 Featured

LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 with an IC50 less than 2 μM.

DC10409 PNU-74654

PNU-74654 is an inhibitor of Wnt/β-catenin pathway with an IC50 of 129.8 μM in NCI-H295 cell.

DC10888 SKL2001 Featured

SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity.

DC10472 Toxoflavin (PKF118-310) Featured

Toxoflavin is an inhibitor of survivin expression and antagonist of Tcf4/b-catenin signaling

DC28730 N-Desmethylnefopam

N-Desmethylnefopam is the main metabolite of Nefopam. N-Desmethylnefopam is a centrally-acting but non-opioid analgesic agent, for the relief of moderate to severe pain. Nefopam targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo.

DC29001 CWP232228 Featured

CWP232228, a highly potent selective Wnt/β-catenin signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 suppresses tumor formation and metastasis without toxicity through the inhibition of the growth of breast and liver cancer stem cells (CSCs).

DC40956 β-catenin-IN-2

β-catenin-IN-2 is a potent β-catenin inhibitor, compound H1B1, extracted from patent US20150374662A1. β-catenin-IN-2 can be used for the study of colorectal cancer.

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