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| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC7753 | Zatebradine hydrochloride | Zatebradine hydrochloride is a bradycardic agent that creates use-dependent inhibition of hyperpolarization-activated current (If) in sinoatrial node cells (EC50 = 480 nM) and Purkinje fibres. |
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| DC9461 | Zatebradine | Zatebradine(UL-FS49) is a potent HCN channels antagonist, which decreased the heartbeat in a reversible manner; 92% inhibition of the hHCN1-mediated current at 10 uM. |
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| DC70477 | HCN4 inhibitor EC18 | HCN4 inhibitor EC18 (EC18) is a HCN4-prefering blocker. |
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| DC73618 | NUCC-0200590 | NUCC-0200590 is a small-molecule inhibitor of the TRIP8b-HCN interaction with IC50 of 7.0 uM in AlphaScreen assays, effectively disrupts the TRIP8b-HCN interaction in vitro and in vivo. |
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| DC73619 | Org 34167 Featured | Org 34167 HCl salt is a broad-spectrum inhibitor of HCN channels with IC50 of 23.4, 8.2 and 9.2 uM for HCN1, HCN2 and HCN4 channels, respectively, slowing activation and causing a hyperpolarising shift in voltage-dependence of activation. |
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| DC73620 | RO-275 | RO-275 is a potent, selective HCN1 ion channel inhibitor with IC50 of 46 nM, displays 311/100/302-fold selectivity over HCN2/HCN3/HCN4. |
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