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HCV Infection

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Cat. No. Product Name Field of Application Chemical Structure
DC10818 ABT-493(Glecaprevir) Featured
Glecaprevir is a novel HCV NS3/4A protease inhibitor, with IC50 values ranging from 3.5 to 11.3 nM.
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DC8238 Danoprevir Featured
Danoprevir is a peptidomimetic inhibitor of the NS3/4A protease of hepatitis C virus (HCV) with IC50 of 0.2-3.5 nM, inhibition effect for HCV genotypes 1A/1B/4/5/6 is ~10-fold higher than 2B/3A.
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DC9751 Velpatasvir(GS5816) Featured
Velpatasvir(GS-5816) is a potent and selective Hepatitis C virus NS5A inhibitor.
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DC10104 VX222(Lomibuvir) Featured
VCH-222(Lomibuvir) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM, 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L.
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DC1008 Telaprevir (VX-950) Featured
Telaprevir (VX-950) is an HCV NS3-4A serine protease inhibitor with IC50 of 0.35 μM.
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DC8190 Ravidasvir hydrochloride (PPI-668) Featured
Ravidasvir(PPI-668) is a NS5A Inhibitor.
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DC4121 PSI6130 Featured
PSI-6130(R 1656) is a Hepatitis C Virus Nucleoside Inhibitor. PSI-6130(R 1656) is useful for Antiviral agents.
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DC10728 Pibrentasvir(ABT-530) Featured
Pibrentasvir is a novel and pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with EC50s ranging from 1.4 to 5.0 pM against HCV replicons containing NS5A from genotypes 1 to 6.
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DC7394 Daclatasvir dihydrochloride (BMS-790052) Featured
Daclatasvir (BMS-790052) is a highly selective inhibitor of HCV NS5A with EC50 of 9-50 pM, for a broad range of HCV replicon genotypes and the JFH-1 genotype 2a infectious virus in cell culture.
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DC7387 Clemizole Hydrochloride Featured
Clemizole is a H1 histamine receptor antagonist.Recently, researchers have identified that clemizole hydrochloride can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication.
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DC5077 Boceprevir(EBP 520; SCH 503034 ) Featured
Boceprevir(EBP 520; SCH 503034 ) is useful for Anti HCV.
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DC8183 Paritaprevir(Veruprevir ABT-450) Featured
NS3/4A protease inhibitor
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DC8832 Clemizole (free base) Featured
Clemizole is a H1 histamine receptor antagonist.Recently, researchers have identified that clemizole hydrochloride can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication.
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DC9462 R-7128(Mericitabine) Featured
R-7128(Mericitabine) is a selective nucleoside analog inhibitor of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, with activity across all HCV genotypes.
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DC11419 Merimepodib Featured
Merimepodib(VX-497) is a novel noncompetitive inhibitor of IMPDH (Inosine monophosphate dehydrogenase).
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DC8612 Simeprevir(TMC-435)
Simeprevir (TMC 435350) is a potent inhibitor of HCV NS3/4A protease (Ki = 0.36 nM) and viral replication (replicon EC50 = 7.8 nM).
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DC8178 Beclabuvir(BMS-791325)
non-nucleoside inhibitor of the NS5B
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DC7609 Isatoribine
Isatoribine is a selective agonist of TLR7
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DC11494 INX-08189
INX-08189 is a phosphoramidate prodrug of O-6-methyl-2-C-methyl guanosine, potent inhibitor of HCV NS5B polymerase with IC50 of 10 nM in replicon assay.
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DC9510 CTS-1027
CTS-1027 is a potent small molecule inhibitor of MMPs(IC50=0.4 nM/0.6 nM for MMP2/MMP13); >1,000 fold selectivity over MMP1.
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DC11081 Coblopasvir
Coblopasvir (KW136, KW-136) is a novel HCV NS5A inhibitor under development for treatment of HCV infection..
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DC11731 Ruzasvir
A potent, pan-genotype HCV NS5A inhibitor with replicon EC90 of 0.003, 0.016, 0.067, 0.036, 0.007, and 0.007 nM for GT1a, GT1a L31V, GT1a Y93H, GT2b, GT3a, and Gt4a, respectively..
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DC11825 MK-8876
A novel, broadly acting non-nucleoside inhibitor of HCV NS5B polymerase with IC50 of 3 nM and 2 nM for GT1b and GT2a, respectively.
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DC11823 BMS-929075
A highly potent, selective, orally bioavailable HCV NS5B polymerase inhibitor with IC50 of 9, 4, and 18 nM for GT1a, GT1b, and GT1b-C316N mutant in HCV replicon assay, respectively.
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