Home > PROTACs > E3 Ligase Ligand
Cat. No. Product name CAS No.
DC11578 VHL Ligand 3

A VHL ligand for PROTAC..

1448189-98-7
DC11581 VHL Ligand 4

A VHL ligand for PROTAC..

1631137-45-5
DC11580 VHL-2

A VHL ligand for PROTAC..

1631137-31-9
DC11588 CC-885

CC-885 (CC 885, CC885) is a novel E3 ligase cereblon (CRBN) modulator with potent anti-tumour activity mediated through the degradation of GSPT1.

1010100-07-8
DC12249 E3 ligase Ligand 1 dihydrochloride

E3 ligase Ligand 1 dihydrochloride is a Hippel-Landau (VHL) E3 ligase-binding moiety based on PROTAC technology.

DC22335 E3 ligase Ligand 1A Featured

E3 ligase Ligand 1A is a ligand of E3 ligase, used in PROTAC technology; E3 ligase Ligand 1A can be used in the research of cancer. (S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM[2].

1948273-02-6
DC11565 E3 Ligase Ligand 2 Featured

E3 ligase Ligand 2 is a Ligand for E3 Ligase used in PROTAC technology.

5054-59-1
DC11571 E3 Ligase Ligand 3 Featured

E3 ligase Ligand 3 is a ligand of E3 ligase, used in PROTAC technology.

1061605-21-7
DC12028 MDK7526(Protein degrader 1) Featured

MDK7526, also known as VHL Ligand 1; Protein degrader 1, is a potent and selective protein degrader.

1448189-80-7
DC20512 VHL ligand 1 Featured

PROTAC-VHL-ligand is a von Hippel–Lindau (VHL) ligand used for the proteolysis targeting chimeras (PROTACs) method, induces target protein degradation..

1448297-52-6
DC11579 VH-032

VH-032 (VHL ligand 1) is a VHL ligand for PROTAC and potent, small molecule inhibitor of the VHL/HIF-1α interaction with Kd of 185 nM..

1448188-62-2
DC26119 VHL ligand 2 hydrochloride Featured

VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader.

1948273-03-7
DC22337 E3 ligase Ligand 4(TC-E3 5032) Featured

E3 ligase Ligand 4 is a ligand of E3 ligase, used in PROTAC technology.

835616-60-9
DC28693 Cereblon modulator 1

Cereblon modulator 1 (compound F) is a cereblon (CRBN) E3 ligase modulator. Cereblon modulator 1 specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex. This leads to the ubiquitination of certain substrate proteins and induces the proteasome-mediated degradation of certain transcription factors, including Ikaros (IKZF1) and Aiolos (IKZF3).

1860875-51-9
DC39709 Lenalidomide-Br Featured

Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs.

2093387-36-9
DC40433 Thalidomide-O-C8-COOH

Thalidomide-O-C8-COOH is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-C8-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs.

2225148-51-4
DC40517 Thalidomide-O-C8-Boc

Thalidomide-O-C8-Boc is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-C8-Boc can be connected to the ligand for protein by a linker to form PROTACs.

2225148-52-5
DC41134 Thalidomide-5-OH Featured

Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs.

64567-60-8
DC42238 Chlorobutanol hemihydrate

Thalidomide 5-fluoride is Thalidomide-based cereblon ligand?that incorporates to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.

835616-61-0
DC42462 Lenalidomide-I

Lenalidomide-I (Compound 72) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570 (HY-112609).

2207541-30-6
DC42463 Thalidomide-NH-CH2-COOH

Thalidomide-NH-CH2-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-NH-CH2-COOH can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032 (HY-123937).

927670-97-1
DC42464 CRBN modulator-1

CRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM.

2407829-65-4
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