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E3 Ligase Ligand

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Cat. No. Product Name Field of Application Chemical Structure
DC79781 (S,S,S)-VH032-cyclopropane-F
(S,S,S)-VH032-cyclopropane-F is a ligand for E3 ubiquitin ligases. (S,S,S)-VH032-cyclopropane-F can be linked to target protein ligands via a linker to form the PROTAC cis-VZ185.
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DC79732 4-[(1E)-2-Nitroethenyl]benzoic acid
4-[(1E)-2-Nitroethenyl]benzoic acid is an E3 ligase ligand. 4-[(1E)-2-Nitroethenyl]benzoic acid can be used for synthesis of PROTAC BRD4 Degrader-38.
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DC79656 E3 ligase Ligand 67
E3 ligase Ligand 67 (Compound 5) is a STUB1/CHIP ligand with a Kd of 8.9  μM for CHIP in fluorescence polarization assay. E3 ligase Ligand 67 is an E3 ligase ligand that can be used for synthesis of PROTACs.
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DC79467 KLHDC2 ligand 1
KLHDC2 ligand 1 is an E3 ligase ligand. KLHDC2 ligand 1 can be used for synthesis of PROTAC BRD4 Degrader-31.
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DC79443 LC3 liagnd-2
LC3 liagnd-2 is an E3 ligase ligand. LC3 liagnd-2 can be used for synthesis of PROTAC PDEδ autophagic degrader 1.
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DC79357 (S,S,S)-AHPC
(S,S,S)-AHPC is an E3 ligase ligand. (S,S,S)-AHPC can be used for synthesis of PROTAC AH081.
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DC79342 CRBN ligand-184
CRBN ligand-184 is a ligand for CRBN-type E3 ubiquitin ligases. CRBN ligand-184 can be used to synthesize PROTAC AU-24118.
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DC79272 N-Demethylonalespib
N-Demethylonalespib is a ligand for E3 ligase. N-Demethylonalespib can be used for synthesis of DDO3602.
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DC79254 Dihydrouracil-Ph-2-Me-piperidine
Dihydrouracil-Ph-2-Me-piperidine is an E3 ligase ligand. Dihydrouracil-Ph-2-Me-piperidine can be used to synthesize PROTAC HPK1 Degrader-6.
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DC79195 Nef ligand-2
Nef ligand-2 is a binder of Nef. Nef ligand-2 is Ligands for E3 Ligase. Nef ligand-2 is the Nef Binder portion of FC-14369.
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DC79044 Thalidomide-C4-N2-C2-N3
Thalidomide-C4-N2-C2-N3 is an E3 ligase ligand. Thalidomide-C4-N2-C2-N3 can bind to a target protein ligand with a linker to form a PROTAC molecule, PROTAC sEH-degrader-4.
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DC78933 E3 ligase Ligand 58
E3 ligase Ligand 58 is an E3 ligase ligand. E3 ligase Ligand 58 can be used for synthesis of PROTAC AH078.
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DC78911 E3 ligase Ligand 76
E3 ligase Ligand 76 is a E3 ligase ligand that can be used in the recruitment of VHL protein. E3 ligase Ligand 76 can be connected to the KRAS ligand by a linker to synthesis of PROTAC KRAS(on) degrader ACBI-4.
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DC78828 Thalidomide-C-amide-C5-amine
Thalidomide-C-amide-C5-amine is an E3 ligase ligand. Thalidomide-C-amide-C5-amine can be used for synthesis of PROTAC BET Degrader-10.
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DC78750 OICR-41103N
OICR-41103N is the negative control form of OICR-41103. OICR-41103 is an effective, selective, cell-active DCAF1 small molecule chemical probe (Ki<2 nM) that targets the DCAF1 WDR domain and replaces the viral Vpr protein.
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DC78749 OICR-41103
OICR-41103 is an effective, selective, cell-active DCAF1 small molecule chemical probe that targets the DCAF1 WDR domain and replaces the viral Vpr protein. The binding Ki value of OICR-41103 and DCAF1 is less than 2 nM.
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DC78748 (S,S,S)-AHPC-Me
(S,S,S)-AHPC-Me is an E3 ligase ligand. (S,S,S)-AHPC-Me can be used for synthesis of PROTAC (4S)-PROTAC SOS1 degrader-1 diTFA.
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DC78731 E3 ligase Ligand 60
E3 ligase Ligand 60 is a ligand for E3 ligase, used for the synthesis of JV8.
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DC78727 (R,S,S)-VH032-Me TFA
(R,S,S)-VH032-Me TFA is an E3 ligase Ligand and can be used for synthesis of dTAGV-1 hydrochloride.
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DC78692 CRBN ligand-186
CRBN ligand-186 is a CRBN-type E3 ubiquitin ligase ligand that can be used to prepare PROTAC.
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DC78682 E3 ligase Ligand 77
E3 ligase Ligand 77 is a CRBN type E3 ubiquitin ligase ligand. E3 ligase Ligand 77 can be used for synthesizing PROTAC, such as PROTAC RET Degrader 1.
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DC78659 E3 ligase Ligand 75
E3 ligase Ligand 75 is an E3 ligase ligand. E3 ligase Ligand 75 can be used for synthesis PROTAC K-Ras Degrader-7.
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DC78597 Deoxy-thalidomide-OMe
Deoxy-thalidomide-OMe is an E3 ligase ligand. Deoxy-thalidomide-OMe can be used for synthesis of PROTAC LRRK2 Degrader-4.
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DC78572 Brigatinib A
Brigatinib A is an GID4 ligand. Brigatinib A can be used for synthesizing PROTAC BCR-ABL Degrader-2.
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DC78498 6-(2,4-Dioxopyrimidin-1-yl)-1-methylindole
6-(2,4-Dioxopyrimidin-1-yl)-1-methylindole is an E3 ligase ligand used in the synthesis of the PROTAC Androgen receptor degrader-1.
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DC78487 XB2M54
XB2M54 is a selective XIAP antagonist. XB2M54 inhibits NOD2-mediated inflammatory signaling. XB2M54 is an E3 ligase ligand. XB2M54 can be used for synthesis of PROTAC ERα Degrader-1.
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DC78218 XIAP ligand 5
XIAP ligand 5 is a XIAP antagonist. XIAP ligand 5 is an E3 ligase ligand. XIAP ligand 5 can be used for synthesis of PROTAC GNE-1567.
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DC78217 CDK12-Cyclin K ligand-1
CDK12-Cyclin K ligand-1 is a ligand of PROTAC degrader that binds to the E3 ligase. CDK12-Cyclin K ligand-1 can be used in the synthesis of PROTAC degrader such as PP-C8.
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DC78213 (S,S,S)-VH032
(S,S,S)-VH032 is the ligand for E3 Ligase (VHL) that can be used for synthesis of PROTAC SGK3 degrader-2.
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DC78212 (R,S,R)-AHPC-Me-Ac
(R,S,R)-AHPC-Me-Ac is an E3 ligase ligand used in the synthesis of the PROTAC SHP2 Protein degrader-2.
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