Home > Inhibitors & Agonists > Nuclear Receptor/Transcription Factor
Cat. No. Product name CAS No.
DC10832 (E/Z)-4-hydroxy Tamoxifen Featured

(E/Z)-4-hydroxy Tamoxifen is an active metabolite of tamoxifen that is formed by the action of cytochrome P450 2D6 in human liver.

68392-35-8
DCE-016 Chenodeoxycholic acid

>98%,Standard References

474-25-9
DCL-047 Sulforaphane

>98%,Standard References

4478-93-7
DC7575 10058-F4 Featured

10058-F4 is a c-Myc inhibitor that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression.

403811-55-2
DC10075 10074-G5 Featured

10074-G5 is a c-Myc Max interaction inhibitor.

413611-93-5
DCAPI1534 Alfacalcidol Featured

1α-Hydroxyvitamin D3 is a form of vitamin D that helps the body absorb calcium from food.

41294-56-8
DCAPI1409 Maxacalcitol

22-Oxacalcitriol is a Vitamin D3 analog which is Non-calcemic as well as a VDR ligand. 22-Oxacalcitriol has been shown to decrease parathyroid hormone (PTH) mRNA expression in vitro. Additionally has been noted to exhibit similar effects to calcitriol in

103909-75-7
DCAPI1508 25-OH-VD2

25-Hydroxyvitamin D2 is used in serum to measure the concentration of vitamin D produced by the skin. It is known that 25-Hydroxyvitamin D2 can be detected in human serum using high-performance liquid chromatography and ultraviolet detection. Vitamin D2,

21343-40-8
DC9044 2-Methoxyestradiol Featured

2-methoxyestradiol (2ME2; NSC-659853) is a natural metabolite of estrogen that is known to inhibit HIF-1 alpha with an IC50 of 0.71 ± 0.11 μM for the inhibition of BPAEC migration.

362-07-2
DC10415 4E2RCat Featured

4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM.

432499-63-3
DC7349 4EGI-1 Featured

4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 μM.

315706-13-9
DC10037 4μ8C Featured

4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM.

14003-96-4
DC10187 666-15 Featured

666-15 is a potent and selective CREB inhibitor with an IC50 of 81 nM.

1433286-70-4
DC11530 Tapinarof (Benvitimod; GSK2894512) Featured

Tapinarof (WBI-1001) is a natural aryl hydrocarbon receptor (AhR) agonist with an EC50 of 13 nM. Tapinarof resolves skin inflammation in mice.

79338-84-4
DC11658 Diptoindonesin G Featured

Dip G is a natural compound, novel chemical probe reciprocally stabilizes ERβ and destabilizes ERα in breast cancer cells; targets CHIP ubiquitin E3 ligase to modulate ER protein stability, enhances the transcription and anti-proliferative activities of ERβ, while attenuating the transcription and proliferative effects of ERα; the first small molecule that can restore the balance of ERα and ERβ.

1190948-58-3
DC11751 UHC1

A novel potent, non-agonist PPARγ ligand that blocks CDK5-mediated PPARγ phosphorylation, without the classical agonism.

1629960-95-7
DC11750 SR-1664

A novel potent, non-agonist PPARγ ligand that blocks the Cdk5-mediated phosphorylation in vitro (IC50=80 nM) and in vivo, without the classical agonism.

1338259-05-4
DC11607 JTZ-951(Enarodustat) Featured

A novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2.

1262132-81-9
DC11608 JTZ-951 hydrochloride

A novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2.

1262131-60-1
DC11985 PSTC

A novel potent, selective Nrf2 activator with pEC50 of 7.7 (inducing of NQO1 specific enzyme activity).

DC11547 LY-2562175 Featured

A novel potent, selective, partial FXR agonist with EC50 of 193 nM.

1103500-20-4
DC11822 YD-277

A novel small molecule KLF5 inhibitor derived from ML264, demonstrates >10-fold enhanced efficacy in multiple cancer cell lines with IC50 of 1.5-10 uM.

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