Cat. No. | Product Name | Field of Application | Chemical Structure |
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DC8913 | Dabigatran etexilate mesylate Featured |
Dabigatran etexilate mesylate (BIBR 1048MS) serves as the orally bioavailable prodrug of the active anticoagulant dabigatran. Following absorption, this precursor compound undergoes enzymatic conversion to release dabigatran - a highly selective, reversible direct thrombin inhibitor (DTI) with exceptional potency (Ki = 4.5 nM).
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DC1010 | BIBR-1048 (Dabigatran etexilate) Featured |
BIBR-1048 (Dabigatran) represents a breakthrough in anticoagulant therapy as a potent, selective direct thrombin inhibitor.
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DC9595 | E-4031 Featured |
E-4031 is a benzenesulfonamide antiarrhythmic agent; blocks the ATP-sensitive potassium channel.
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DC10700 | Seladelpar Featured |
Seladelpar is a selective peroxisome proliferator-activated receptor (SPPAR) -δ receptor agonist.
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DC11547 | LY-2562175 Featured |
LY2562175 is a potent and selective FXR agonist, with an EC50 of 193 nM.
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DC7224 | PD 123319 Featured |
PD 123319 is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.
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DC9861 | BMS-779788(XL-652) Featured |
BMS-779788(XL652) is a novel small-molecule modulator of the Liver X Receptor (LXR), a nuclear hormone receptor implicated in a variety of cardiovascular and metabolic disorders.
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DC1009 | Laropiprant Featured |
MK 0524 is a potent, selective DP1 receptor antagonist with Ki values of 0.57 nM and 0.75 µM for the DP1 and DP2 receptors, respectively.
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DC8471 | CGS 21680 hydrochloride Featured |
CGS 21680 hydrochloride is an A2A adenosine receptor agonist (Ki = 27 nM).
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DC10446 | (3R,4S,5S)-tert-butyl 3-Methoxy-5-Methyl-4-(MethylaMino)heptanoate hydroc hloride Featured |
Diltiazem hydrochloride is a calcium ion influx inhibitor (slow channel blocker or calcium antagonist).
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DC1101 | Ticagrelor (Brilinta,AZD6140) Featured |
Ticagrelor is the first reversibly binding oral P2Y12 receptor antagonist, also inhibits CYP2C9 and 4-hydroxylation with IC50 of 10.5 μM and 8.2 μM respectively.
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DC1094 | Avasimibe Featured |
Avasimibe inhibits ACAT and CYP2C9 with IC50 of 3.3 μM and 2.9 μM, respectively.
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DC4233 | GW501516 Featured |
GW501516 is the most selective and potent PPARβ (EC50=1.1nM) agonist that has been demonstrated to be 1,000-fold more selective in comparison to existing subtypes.
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DC7782 | BAY 41-2272 |
Activator of soluble guanylyl cyclase (sGC); acts at a nitric oxide (NO)-independent regulatory site in the sGC α1 subunit. Inhibits platelet aggregation (IC50 = 36 nM) and phenylephrine-induced contractions of rabbit aorta (IC50 = 0.30 μM). Also reduces vascular smooth muscle growth through cAMP- and cGMP-dependent PKA and PKG pathways.. For the detailed information of BAY 41-2272, the solubility of BAY 41-2272 in water, the solubility of BAY 41-2272 in DMSO, the solubility of BAY 41-2272 in PBS buffer, the animal experiment (test) of BAY 41-2272, the cell expriment (test) of BAY 41-2272, the in vivo, in vitro and clinical trial test of BAY 41-2272, the EC50, IC50,and affinity,of BAY 41-2272, Please contact DC Chemicals.
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DC11923 | BMS-986120 Featured |
BMS-986120 (BMS986120) is a potent, selective, orally bioavailable, and reversible PAR4 antagonist with Kd of 0.098 nM for human PAR4.
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DC10386 | Tenapanor Featured |
Tenapanor is an inhibitor of the Na+/H+ exchanger NHE3 with IC50 values of 5 and 10 nM against human and Rat NHE3, respectively.
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DC7699 | VTP-27999 Featured |
VTP-27999 is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.
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DC8860 | Vorapaxar Featured |
Vorapaxar (SCH 530348) is a potent and orally active thrombin receptor (PAR-1) antagonist with Ki of 8.1 nM.
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DC8916 | Vanoxerine dihydrochloride Featured |
Vanoxerine 2 Hcl(GBR12909) is a potent and selective DRI (Dopamine reuptake inhibitor).
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DC9489 | Tirofiban (hydrochloride monohydrate) Featured |
Tirofiban hydrochloride monohydrate is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist
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DC4108 | Sitaxentan sodium Featured |
Sitaxentan sodium (TBC-11251) is a selective endothelin receptor-A antagonist with IC50 and Ki of 1.4 nM and 0.43 nM, respectively.
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DC9313 | Sarpogrelate (hydrochloride) Featured |
Sarpogrelate(MCI-9042) hydrochloride, a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD.
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DC5108 | BAY 59-7939 (Rivaroxaban) Featured |
Rivaroxaban (Xarelto; BAY 59-7939) is a novel, oral, direct Factor Xa (FXa) inhibitor in late-stage development for the prevention and treatment of thromboembolic disorders.
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DC10012 | Pirmenol hydrochloride Featured |
Pirmenol hydrochloride inhibits IK.ACh by blocking muscarinic receptors. The IC50 of Pirmenol for inhibition of Carbachol-induced IK.ACh is 0.1 μM.
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DC10500 | PF-06282999 Featured |
PF-06282999 is a potent and selective myeloperoxidase inhibitor which is potential useful for the treatment of cardiovascular diseases.
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DC11360 | Pemafibrate Featured |
Pemafibrate is an orally bioavailable and selective agonist of peroxisome proliferator-activated receptor α (PPARα; EC50 = 1 nM for transcriptional activity), a transcription factor that is essential for regulation of lipid homeostasis.
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DC7711 | Losmapimod Featured |
Losmapimod (GW856553X) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively. Phase 3.
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DC9153 | Losartan Potassium Featured |
Losartan is an angiotensin II receptor antagonist, competes with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
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DC7707 | LCZ-696 Featured |
LCZ696 is a first-in-class dual inhibitor of the angiotensin II receptor(AT II receptor) and neprilysin; a novel single molecule comprising molecular moieties of valsartan and NEP inhibitor prodrug AHU377 (1:1 ratio).
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DCAPI1084 | Ezetimibe (Zetia) Featured |
Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
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