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COPD

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Cat. No. Product Name Field of Application Chemical Structure
DCAPI1449 Tiotropium Bromide Featured
Tiotropium Bromide is a muscarinic acetylcholine receptor (mAChR M) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel. This stops signaling between neurons and leads to muscle relaxation.
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DC7516 TG100-115 Featured
TG100115 is a PI3Kγ/δ inhibitor with IC50 of 83 nM/235 nM, with little effect on PI3Kα/β. Phase 1/2.
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DC9248 Olodaterol(BI-1744) hydrochloride Featured
Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs.
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DC8779 Glycopyrrolate Featured
Glycopyrrolate(Glycopyrronium Br) is a muscarinic competitive antagonist used as an antispasmodic.
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DC10384 Olodaterol Featured
Olodaterol (BI1744) is a long acting β2-adrenoceptor agonist with an EC50 of 1.4±0.08 nM.
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DC8813 TD-4208 Featured
TD-4208 is a potent and selective inhaled muscarinic antagonist with functional lung selectivity and long duration of action in preclinical models of bronchoconstriction.
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DC8153 Umeclidinium bromide Featured
Umeclidinium bromide(GSK573719A) is a muscarinic receptor antagonist which is useful in treatment of chronic obstructive pulmonary disease (COPD).
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DC9689 Danirixin (GSK1325756) Featured
Danirixin(GSK1325756) is a selective CXCR2 antagonist.
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DC8767 GSK256066 Featured
GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.
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DC10417 Acumapimod (BCT197) Featured
Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 μM for p38α.
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DC11723 AZD-7986(Brensocatib) Featured
AZD-7986(Brensocatib) is a highly potent, reversible, and selective DPP1 inhibitor with enzyme and cell pIC50 of 8.4.
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DC10021 Batefenterol Featured
Batefenterol(GSK961081,TD-5959)is a Muscarinic Antagonist and β2-Agonist possessing both muscarinic antagonist (MA) and β2-adrenoceptor agonist (BA) properties (MABA).
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DC9410 SCH 527123
SCH-527123 is a potent antagonist of both CXCR1 and CXCR2 with IC50 of 42 nM and 3 nM, respectively.
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DC9944 PI3Kδ inhibitor GS2292767
GSK2292767 is a potent and selective PI3Kδ inhibitor.
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DC9943 PI3Kδ inhibitor GS2269557
GSK-2269557 is a potent and selective PI3Kδ inhibitor over the closely related isoforms.
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DC9582 Cilomilast
Cilomilast(SB 207499; Ariflo) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity.
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DC11859 BAY85-8501
BAY 85-8501 (BAY85-8501) is a potent, selective human neutrophil elastase (HNE) inhibitor with IC50 of 65 pM.
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DC11868 Freselestat
A potent, selective and orally active human neutrophil elastase (HNE) inhibitor with Ki of 12 nM.
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