Home > Inhibitors & Agonists > Proteasome/Ubiquitin > E3 Ubiquitin Ligase
Cat. No. Product name CAS No.
DC11922 BC-1382

A potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction with IC50 of 5 nM.

1013753-99-5
DC10146 CC-122(Avadomide) Featured

CC-122 is a novel agent for DLBCL with antitumor and immunomodulatory activity.CC-122 binds CRBN and degrades Aiolos and Ikaros resulting in a mimicry of IFN signaling and apoptosis in DLBCL.

1015474-32-4
DC10174 Iberdomide Featured

Iberdomide (CC-220) is a cereblon modulator in clinical development for systemic lupus erythematosis. Iberdomide exhibits an IC50 of 60 nM in TR-FRET cereblon binding assay.

1323403-33-3
DC9269 PRT4165(NSC-600157) Featured

PRT4165 is a potent inhibitor of PRC1 (Polycomb-repressive complex 1)-mediated H2A ubiquitylation.

31083-55-3
DC10710 Skp2 Inhibitor C1(SKPin C1) Featured

Skp2 Inhibitor C1(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation, selectively inhibited Skp2-mediated p27 degradation by reducing p27 binding through key compound-receptor contacts.

432001-69-9
DC12349 TAME hydrochloride

TAME hydrochloride is an inhibitor of anaphase-promoting complex (APC), which prevents its activation by Cdc20 and Cdh1.

1784-03-8
DC7312 Tasisulam(LY573636) Featured

Tasisulam sodium is The sodium salt of an acyl-sulfonamide with potential antineoplastic activity.

519055-62-0
DC39084 CC-92480

CC-92480 is a novel protein degrader and a cereblon E3 ligase modulator (CELMoD) that has anti-myeloma activity.

2259648-80-9
DC44890 Cbl-b-IN-1

Cbl-b-IN-1 (example 519) is a Cbl-b inhibitor, extracted from patent WO2019148005A1, with an IC50 <100 nM.

2368841-84-1
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