Cat. No. | Product name | CAS No. |
DC10649 |
AX15836
Featured
AX15836 is a highly potent and selective ERK5 inhibitor. |
2035509-96-5 |
DC10985 |
AZ6197
AZ6197 (AZ-6197) is a potent, selective, reversible inhibitor of ERK1/2 with IC50 of <0.3 nM (ERK2), inhibits pERK/pRSK with IC50 of 12/62 nM in A375 cells, respectively. |
2023003-94-1 |
DC11481 |
AZD-0364
AZD-0364 is a potent and selective ERK2 inhibitor extracted from patent WO2017080979A1, compound example 18, has an IC50 of 0.6 nM. |
2097416-76-5 |
DC8866 |
DEL-22379
Featured
DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ∼0.5 μM. |
181223-80-3 |
DC10487 |
KO947
Featured
KO-947 is a small molecule inhibitor of extracellular-signal-regulated kinases 1 and 2 (ERK1/2), as a potential treatment for cancers in which the mitogen activated protein kinase (MAPK) pathway. |
1695533-89-1 |
DC10640 |
LY3214996
LY3214996 is a selective and novel ERK1/2 inhibitor with IC50 of 5 nM for both enzymes in biochemical assays. It potently inhibits cellular phospho-RSK1 in BRAF and RAS mutant cancer cell lines. |
1951483-29-6 |
DC7283 |
SCH-772984
Featured
SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively. |
942183-80-4 |
DC7285 |
FR 180204
Featured
Selective ERK inhibitor (IC50 values are 0.14 and 0.31 μM for ERK2 and ERK1 respectively). Displays 30-fold selectivity for ERK over p38α (IC50 = 10 μM); displays no activity against human recombinant MEK1, MKK4, IKKα, PKCα, Src, Syc and PDGFα. |
865362-74-9 |
DC8384 |
Sodium Tauroursodeoxycholate (TUDC)
Featured
Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, used for the treatment of gallstones and liver cirrhosis. |
35807-85-3 |
DC7242 |
VX-11e(TCS ERK 11e)
Featured
VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK (Extracellular Signal-Regulated Kinase); antitumor agent. |
896720-20-0 |
DC10979 |
BAY-885
Featured
BAY-885 is a highly potent, selective ERK5 (MAPK7) inhibitor with IC50 of 40 nM. |
2307249-33-6 |
DC28723 |
ERK-IN-2
ERK-IN-2 is a potent, highly seletive and orally active ERK2 inhibitor probe with an IC50 value of 1.8 nM. ERK-IN-2 might lead to off-target toxicity and/or off-target activity at dose >10 μM. |
|
DC40360 |
ERK1/2 inhibitor 2
ERK1/2 inhibitor 2 (Example 1) is a potent dual ERK1/2 inhibitor. ERK1/2 inhibitor 2 has anti-cancer activity. |
2095719-92-7 |
DC42122 |
Pamoic acid disodium
Pamoic acid disodium is a potent GPR35 agonist with an EC50 value of 79 nM. Pamoic acid disodium induces GPR35 internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively. Pamoic acid disodium potently recruits β-arrestin2 to GPR35 and has an antinociceptive effect. |
6640-22-8 |
DC42417 |
ERK-IN-3
ERK-IN-3 is a potent and oral of ERK. ERK-IN-3 inhibits ERK1/2 with low single-digit nM IC50 values. ERK-IN-3 has the potential to be used to study cancers driven by RAS mutations. |
2055597-12-9 |