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Depression

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Cat. No. Product Name Field of Application Chemical Structure
DC12271 JNJ-54175446 Featured
JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively.
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DC9098 Paroxetine HCl Featured
Paroxetine hydrochloride hemihydrate is a antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs).
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DC9765 CERC-501(LY-2456302,Aticaprant) Featured
CERC-501(LY-2456302) is a potent, selective antagonist of the kappa opioid receptor (KOR) (Ki = 0.81 nM vs. 24.0 nM and 155 nM for the μ-opioid receptor (MOR) and δ-opioid receptor (DOR), respectively.
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DC11469 APD125(Nelotanserin) Featured
Nelotanserin is a potent 5-HT2A inverse agonist, a moderately potent 5-HT2C partial inverse agonist and a weak 5-HT2B inverse agonist, with IC50s of 1.7, 79, 791 nM in IP accumulation assays, respectively.
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DC8175 Rapastinel(GLYX-13) Featured
Rapastinel(GLYX-13) is a NMDA receptor partial agonist that acts at the glycine site.
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DC8824 Traxoprodil Featured
Traxoprodil is an NMDA ε 2 (NR2B) antagonist that has been studied as an alternative to serotonin selective reuptake inhibitors.
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DC8476 ACY-738 Featured
ACY-738 demonstrates inhibitory activity against recombinant HDAC6 with IC50 values of 1.7 nM, with respective average selectivity over class I HDACs being 100-fold.
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DC12493 HT-2157(SNAP37889) Featured
HT-2157 (SNAP 37889) is a selective, high-affinity, competitive antagonists of galanin-3 receptor (Gal3).
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DC9513 Radafaxine (hydrochloride) Featured
Radafaxine Hcl(BW-306U; GW-353162A) is a potent metabolite of bupropion; selective for inhibiting the reuptake of norepinephrine over dopamine; DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulat
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DC10394 Org-26576
Org 26576 is a AMPA receptor positive allosteric modulator.
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DC9319 Setiptiline
Setiptiline(Org-8282) is a serotonin receptor antagonist.
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DC9320 Setiptiline (maleate)
Setiptiline is a serotonin receptor antagonist.
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DC3171 Agomelatine
Agomelatine is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor.
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