Home > Inhibitors & Agonists > GPCR > Protease-activated Receptor (PAR)
Cat. No. Product name CAS No.
DC10117 AC264613 Featured

AC264613 is a potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 7.5). Displays no activity at other PAR subtypes and exhibits no significant activity at over 30 other receptors implicated in nociception and inflammation.

DC10879 AZ3451 Featured

AZ3451 is a potent and selective allosteric antagonist of protease-activated receptor 2 (PAR2)

DC11742 AZ-8838

AZ-8838 (AZ8838) is a potent, and selective PAR2 antagonist with Kd of 125 nM.

DC11923 BMS-986120

BMS-986120 (BMS986120) is a potent, selective, orally bioavailable, and reversible PAR4 antagonist with Kd of 0.098 nM for human PAR4.

DC8533 E5555 hydrobromide

E5555 shows potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC values of 0.064 and 0.031 μM respectively.

DC11741 GB-110

GB-110 is a potent, non-peptidic agonist of PAR2 that selectively induces PAR2-mediated intracellular Ca(2+) release in HT29 cells with EC50 of 0.28 uM.

DC11740 GB-88

GB-88 is a selective, orally available PAR2 antagonist that inhibits PAR2 activated Ca(2+) release with IC50 of 2 uM.

DC7197 ML 161 Featured

Inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). Thought to act allosterically. Also inhibits thrombin-induced platelet activation.

DC8860 Vorapaxar Featured

Vorapaxar (SCH 530348) is a potent and orally active thrombin receptor (PAR-1) antagonist with Ki of 8.1 nM.

DC40079 PZ-128

PZ-128 (P1pal-7), a cell-penetrating lipopeptide pepducin, is a first-in-class, specific and reversible protease-activated receptor-1 (PAR1) antagonist. PZ-128 targets the cytoplasmic surface of PAR1 and interrupts signaling to internally-located G (PAR1-G) proteins. PZ-128 has antiplatelet, anti-metastatic, anti-angiogenic and anticancer effects.

DC40104 RWJ-56110 dihydrochloride

RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits the aggregation of human platelets induced by?both?SFLLRN-NH2?(IC50=0.16 μM) and thrombin (IC50=0.34 μM), quite selective?relative to U46619 (HY-108566). RWJ-56110 dihydrochloride blocks angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 dihydrochloride induces cell apoptosis.

DC40332 ENMD-1068 hydrochloride

ENMD-1068 hydrochloride is a selective protease-activated receptor 2 (PAR2) antagonist with antiangiogenic and anti-inflammatory activities. ENMD-1068 hydrochloride reduces epatic stellate cells (HSCs) activation and collagen expression through the inhibiton of TGF-β1/Smad signal transduction.


FSLLRY-NH2 is a protease-activated receptor 2 (PAR2) inhibitor.


FSLLRY-NH2 TFA is a protease-activated receptor 2 (PAR2) inhibitor.

DC41701 tcY-NH2

tcY-NH2 is a selective rat PAR4 antagonist peptide. tcY-NH2 inhibits thrombin- and AY-NH2-induced rat platelet aggregation.

DC41702 tcY-NH2 TFA

tcY-NH2 TFA is a selective rat PAR4 antagonist peptide. tcY-NH2 TFA inhibits thrombin- and AY-NH2-induced rat platelet aggregation.


SLIGRL-NH2 TFA (Protease-Activated Receptor-2 Activating Peptide TFA) is an agonist of Protease-Activated Receptor-2 (PAR-2).

DC41761 PAR 4 (1-6) (TFA)

PAR 4 (1-6) TFA (GYPGQV TFA), a hexapeptide, is a fragment of protease-activated receptor 4 (PAR4) and acts as PAR4-specific agonist.

DC41909 TRAP-6 amide

TRAP-6 amide is a PAR-1 thrombin receptor agonist peptide.

DC41910 TRAP-6 amide TFA

TRAP-6 amide TFA is a PAR-1 thrombin receptor agonist peptide.

DC42020 Protease-Activated Receptor-1, PAR-1 Agonist

Protease-Activated Receptor-1, PAR-1 Agonist is a thrombin-specific, protease-activated receptor 1 (PAR-1)-specific agonist peptide.

DC42021 Protease-Activated Receptor-3 (PAR-3) (1-6), human

Protease-Activated Receptor-3 (PAR-3) (1-6), human is a proteinase-activated receptor (PAR-3) agonist peptide.

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