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Cat. No. Product name CAS No.
DC10428 (1S,3R,5R)-PIM447 dihydrochloride

(1S,3R,5R)-PIM447 (dihydrochloride) an PIM inhibitor extracted from patent US 20100056576 A1, compound example 72, has IC50 values of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3.

DC8256 AS 602801(Bentamapimod) Featured

AS 602801(Bentamapimod) is a novel, orally active inhibitor of JNK.

DC5012 AZD-1208 Featured

AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity.

DC9704 Unii-G55ZH52P57 Featured

BTZ043 is a inhibitor of decaprenyl-phosphoribose-epimerase (DprE1), It can display nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.

DCAPI1392 BTZ043 racemate Featured

BTZ043 racemate is a decaprenylphosphoryl-β-D-ribose 2-epimerase (DprE1) inhibitor acting as a new antimycobacterial agent that kill Mycobacterium tuberculosis.

DC7153 CX6258 Featured

CX-6258 is a potent, orally efficacious Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor with excellent biochemical potency and kinase selectivity.

DC10171 Hispidulin Featured

Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC50 of 2.71 μM.

DC10918 INCB053914

INCB053914 (INCB-053914) is a novel potent, and selective ATP-competitive, pan-PIM kinase inhibitor with IC50 of 0.24/30.0/0.12 nM for PIM1/2/3, respectively.

DC10748 NSC31205 Featured

NSC 31205 is a PIM2/1 inhibitor.

DC9593 Pim1/AKK1-IN-1

PIM/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively; also inhibits MPSK1 and TNIK.

DC10047 PIM-447 dihydrochloride Featured

PIM447 is novel pan-PIM kinase inhibitor, including Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase.

DC7236 Pimobendan Featured

Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM.

DC8604 Pim-1 Inhibitor 2

Potent Pim-1 kinase inhibitor (Ki = 91 nM).

DC7160 SGI-1776 Featured

SGI-1776 is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM; 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin.

DC10514 SMI-16a Featured

SMI-16a is a selective Pim kinase inhibitor with IC50 values of 0.15, 0.02 and 48 μM for Pim1, Pim2 and PC3 cells, respectively.

DC7503 SMI 4a Featured

SMI-4a is a potent inhibitor of Pim1 with IC50 of 17 nM, modest potent to Pim-2, does not significantly inhibit other serine/threonine- or tyrosine-kinases.

DC7514 TCS PIM-1 1 Featured

TCS PIM-1 1 is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2(IC50s >20,000 nM).

DC10031 TP-3654 Featured

TP-3654 is a small molecule pan-Pim (PIM) kinase inhibitor.

DC11436 YLT-11 Featured

YLT-11 is a novel and specific PLK4 inhibitor with IC50 of 22 nM and Kd of 5.2 nM.

DC44020 PIM1-IN-1

PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC50 of 262 nM. PIM1-IN-1 shows no obvious effect on FLT3 or hERG binding. Antiproliferative and anti-cancer activity.

DC45197 R8-T198wt

R8-T198wt is a cell-permeable carboxyl-terminal p27Kip1 peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase.

DC47380 MNK/PIM-IN-1

MNK/PIM-IN-1 represents an innovative dual MNK/PIM inhibitor with a good pharmacokinetic profile.

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