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Home > Inhibitors & Agonists > Autophagy > Salt Inducible Kinase (SIK)

Salt Inducible Kinase (SIK)

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Cat. No. Product Name Field of Application Chemical Structure
DC72558 GLPG3970 Featured
GLPG3970 (compound 88) is a first-in-class SIK2/SIK3 inhibitor. GLPG3970 can be used for the research of inflammation and autoimmune disease.
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DC73149 SK-124
SK-124 (SK124) is a potent, selective, orally active SIK2/SIK3 inhibitor with IC50 of 8.8/11.3 nM in cell-based NanoBRET assays, 15-fold selectivity versus SIK1.
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DC73148 JRD-SIK1/2i-4
JRD-SIK1/2i-4 is a potent, highly selective SIK1/2 inhibitor, modulates innate immune activation and suppress intestinal inflammation.
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DC73147 GLPG3312
GLPG3312 is a potent and selective pan-SIK inhibitor with IC50 of 2.0/0.7/0.6 nM for SIK1/SIK2/SIK3, respectively.
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DC10778 YKL-06-061 Featured
YKL-06-061 is a potent and selective SIK (salt-inducible kinase) inhibitor.
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DC10824 ARN-3236 Featured
ARN-3236 is potent, orally active and selective SIK2 inhibitor. ARN-3236 inhibited the growth of 10 ovarian cancer cell lines at an IC50 of 0.8 to 2.6 μmol/L.
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DC46639 WH-4-025 Featured
WH-4-025 is a Salt-inducible kinase (SIK) inhibitor (WO2016023014 A2).
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DC46043 MRIA9
MRIA9 is an ATP-competitive, pan Salt-Inducible kinase (SIK) and PAK2/3 inhibitor, with IC50 values of 516 nM, 180 nM and 127 nM for SIK1, SIK2 and SIK3, respectively.
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