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Dyslipidemia

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Cat. No. Product Name Field of Application Chemical Structure
DC10700 Seladelpar Featured
Seladelpar is a selective peroxisome proliferator-activated receptor (SPPAR) -δ receptor agonist.
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DC11547 LY-2562175 Featured
LY2562175 is a potent and selective FXR agonist, with an EC50 of 193 nM.
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DC1009 Laropiprant Featured
MK 0524 is a potent, selective DP1 receptor antagonist with Ki values of 0.57 nM and 0.75 µM for the DP1 and DP2 receptors, respectively.
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DC1094 Avasimibe Featured
Avasimibe inhibits ACAT and CYP2C9 with IC50 of 3.3 μM and 2.9 μM, respectively.
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DC4233 GW501516 Featured
GW501516 is the most selective and potent PPARβ (EC50=1.1nM) agonist that has been demonstrated to be 1,000-fold more selective in comparison to existing subtypes.
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DC10386 Tenapanor Featured
Tenapanor is an inhibitor of the Na+/H+ exchanger NHE3 with IC50 values of 5 and 10 nM against human and Rat NHE3, respectively.
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DC11360 Pemafibrate Featured
Pemafibrate is an orally bioavailable and selective agonist of peroxisome proliferator-activated receptor α (PPARα; EC50 = 1 nM for transcriptional activity), a transcription factor that is essential for regulation of lipid homeostasis.
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DC9252 BMS-687453 Featured
BMS687453 is a potent and selective peroxisome proliferator activated receptor (PPAR) α agonist, with an EC50 of 10 nM for human PPARα and ∼410-fold selectivity vs human PPARγ in PPAR-GAL4 transactivation assays.
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DCAPI1468 Rosuvastatin Calcium Featured
A selective, competitive inhibitor of HMG-CoA reductase, that is also antilipemic.
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DCAPI1349 Simvastatin (Zocor) Featured
Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM.
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DC7422 GSK1292263 Featured
GSK1292263 is a novel GPR119 receptor agonist used for the treatment of type 2 diabetes.
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DC7933 Ro 48-8071 fumarate Featured
Ro 48-8071 fumarate is an inhibitor of OSC(Oxidosqualene cyclase; IC50=6.5 nM) that has low-density lipoprotein (LDL) cholesterol lowering activity.
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DC7040 WAY-362450 (XL335; Turofexorate isopropyl) Featured
WAY-362450 (XL335; Turofexorate isopropyl) is a highly potent, selective, and orally active farnesoid X receptor (FXR) agonist with an EC50 of 4 nM.WAY-362450 is useful for dyslipidemia.
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DC10134 Obicetrapib (AMG-899,TA-8995) Featured
Obicetrapib is a CETP inhibitor, on the elevation of high-density lipoprotein cholesterol (HDL-C) and reduction of low-density lipoprotein cholesterol (LDL-C), alone and in combination with statin therapy.
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DC7125 Evacetrapib (LY2484595) Featured
Evacetrapib (LY2484595) is a potent and selective inhibitor of CETP with IC50 of 5.5 nM, elevates HDL cholesterol without increases in aldosterone or blood pressure.
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DCAPI1442 Atorvastatin Calcium Featured
Atorvastatin Calcium
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DC6903 Lapaquistat Acetate (TAK-475)
Protective effects of a squalene synthase inhibitor, lapaquistat acetate (TAK-475), on statin-induced myotoxicity in guinea pigs.
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DC11098 CKD-519
CKD-519 (Rocacetrapib, CKD519) is a potent, selective cholesteryl ester transfer protein (CETP) inhibitor, inhibits the CETP-mediated transfer of cholesteryl ester in human serum with IC50 of 2.3 nM.
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