Cat. No. | Product Name | Field of Application | Chemical Structure |
---|---|---|---|
DC9691 | Piperlongumine Featured |
Piperlongumine induces cell death and increases the level of reactive oxygen species (ROS) in cancer cells with both wild-type and normal p53.
More description
|
![]() |
DC46604 | CMD178 Featured |
CMD178 is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling. CMD178 also is an inhibitor of STAT5 and inhibit Treg cell development.
More description
|
![]() |
DC73591 | WZ-2-033 |
WZ-2-033 is a potent, selective STAT3 inhibitor, binds to the SH2 domain of the STAT3 protein with KD of 7.4 uM, disrupts STAT3 dimerization and significantly inhibits STAT3 signaling.
More description
|
![]() |
DC73590 | WB737 |
WB737 is a potent and selective STAT3 inhibitor, directly binds to the STAT3 Src homology 2 (SH2) domain with KD value of 1.34 nM.
More description
|
![]() |
DC73589 | WB436B |
WB436B is a potent and highly selective small molecule inhibitor of STAT3, specifically targets the STAT3-SH2 domain with KD value of 94.3 nM.
More description
|
![]() |
DC73588 | W2014-S |
W2014-S is a small molecule STAT3 inhibitor with binding Kd of 3.64 uM, disrupts STAT3 dimerization and selectively inhibits STAT3 signaling.
More description
|
![]() |
DC73587 | W1131 |
W1131 is a potent and selective STAT3 inhibitor with Kd of 7.55 uM in surface plasmon resonance (SPR) assays, inhibits STAT3 Tyr705 phosphorylation, triggers ferroptosis and possesses potent anti-tumor effects both in vitro and in vivo.
More description
|
![]() |
DC73586 | W1046 |
W1046 is a potent and selective STAT3 inhibitor, decreases the expression of VISTA at mRNA and protein level and inhibits proliferation and survival in AML cells.
More description
|
![]() |
DC73585 | TR120 |
TR120 (TR-120) is a potent small molecule STAT5 inhibitor, exhibits antiproliferative in K562 cells with IC50 of 0.12 uM, decreases STAT5 expression in imatinib-sensitive and imatinib-resistant BCR-ABL-expressing leukemia cells.
More description
|
![]() |
DC73584 | SF-1-088 |
SF-1-088 is a small molecule STAT5-SH2 domain inhibitor with Ki of 8.3 uM (Stat5b), shows no affinity for Stat1 and Stat3 (Ki>25 uM).
More description
|
![]() |
DC73583 | ODZ10117 |
ODZ10117 is a small molecule inhibitor of STAT3, effectively inhibits the level of tyrosine phosphorylated STAT3 in various cancer cell lines.
More description
|
![]() |
DC73582 | MNS1-MV |
MNS1-MV is a novel pyrazole-based small molecular inhibitor of STAT3 pathway, potently inhibit IL-6-induced STAT3 phosphorylation at 10 μM in dBT114 cells.
More description
|
![]() |
DC73581 | MNS1-Leu |
MNS1-Leu is a novel pyrazole-based small molecular inhibitor of STAT3 pathway, potently inhibit IL-6-induced STAT3 phosphorylation at 10 μM in dBT114 cells.
More description
|
![]() |
DC73580 | MC0704 |
MC0704 (MC-0704) is a novel synthetic STAT3 pathway inhibitor, exhibits potential antitumor activity in vitro and in vivo models in docetaxel-resistant TNBC cells.
More description
|
![]() |
DC73579 | LLL12B |
LLL12B is a selective STAT3 inhibitor that suppresses Th17 development, specifically inhibits STAT3 and suppresses Th17 differentiation and expansion.
More description
|
![]() |
DC73578 | K1836 |
K1836 is a small molecule Stattic analog inhibitor of STAT3 signalling.
More description
|
![]() |
DC73577 | DR-1-55 |
DR-1-55 (DR-155) is a selective STAT3 inhibitor that covalently modifies a cysteine in the SH2 domain of STAT3.
More description
|
![]() |
DC45278 | Colivelin Featured |
Colivelin is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro. Colivelin exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin has the potential for the treatment of alzheimer's disease and ischemic brain injury
More description
|
![]() |
DC8726 | FLLL31 Featured |
FLLK31 is a potent and selective inhibitor of the STAT3 signaling pathway.
More description
|
![]() |
DC10139 | Stat5 Inhibitor(STAT5-IN-1) Featured |
Stat5 Inhibitor is a cell permeable nonpetidic nicotinoyl hydrazone which suppresses Stat5 via binding to the SH2 domain.
More description
|
![]() |
DC8474 | Napabucasin (BBI608) Featured |
Napabucasin (BBI608) is an orally-administered small molecule which can block cancer stem cell (CSC) self-renewal and induces cell death in CSCs as well as non-stem cancer cells.
More description
|
![]() |
DC7751 | FLLL32 Featured |
FLLL32, a novel curcumin analogue, is a potent STAT3 inhibitor.
More description
|
![]() |
DC10864 | C188-9 Featured |
C188-9 is a potent inhibitor of STAT3 that binds to STAT3 with high affinity (KD=4.7±0.4 nM). C188-9 is well tolerated in mice, shows good oral bioavailability, and is concentrated in tumors.
More description
|
![]() |
DC11420 | AS-1517499 Featured |
AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM.
More description
|
![]() |
DC72357 | inS3-54-A18 |
inS3-54A18 is a potent inhibitor of STAT3 with anti-cancer properties.
More description
|
![]() |
DC72356 | GYY4137 |
GYY4137 is a novel, water-soluble hydrogen sulfide (H2S)–releasing molecule with vasodilator and antihypertensive activity. GYY4137 shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway. GYY4137 also shows anti-inflammatory activity.
More description
|
![]() |
DC72355 | STX-0119 |
STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.
More description
|
![]() |
DC72211 | HP590 |
HP590 is an orally active, novel and potent STAT3 inhibitor (STAT3 luciferase activity: IC50=27.8 nM; ATP inhibition: IC50=24.7 nM). HP590 shows anti-proliferative activity to gastric cancer cells and induces apoptosis.
More description
|
![]() |
DC72046 | PM-81I |
PM-81I is a potent STAT6 inhibitor (targeting the SH2 structural domain) that effectively reduces STAT6 phosphorylation levels. PM-81I can be used in studies of allergic lung disease, allergic rhinitis, chronic obstructive pulmonary disease or cancer[1].
More description
|
![]() |
DC72045 | (S)-PM-43I |
(S)-PM-43I is a potent STAT6 inhibitor and can reduce STAT6 phosphorylation level. (S)-PM-43I can be used in allergic lung disease, allergic rhinitis, chronic pulmonary obstructive disease and cancer research[1].
More description
|
![]() |