Home > Inhibitors & Agonists > Immunology/Inflammation > NOD-like Receptor (NLR)
Cat. No. Product name CAS No.
DC10620 CY-09 Featured

CY-09 is an NLRP3 inhibitor.

1073612-91-5
DC10483 INF39 Featured

INF39 is an irreversible and noncytotoxic NLRP3 inhibitor.

866028-26-4
DC10142 ML130 Featured

ML-130 is a potent and selective inhibitor of NOD1; displays 36-fold selectivity for NOD1 over NOD2 (IC50 values are 0.56 and >20 μM for NOD1 and NOD2 respectively).

799264-47-4
DC9930 NOD-IN-1 Featured

NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC50 of 5.74 μM and 6.45 μM, respectively.

132819-92-2
DC9254 MCC950 (CP-456773) sodium Featured

MCC950 (CP-456773) sodium is a potent, selective, small-molecule inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs.

256373-96-3
DC40227 Trimethylamine N-oxide

Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway.

1184-78-7
DC40974 GSK717

GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells.

1595278-21-9
DC44152 MCC7840 sodium

MCC7840 sodium, a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM. MCC7840 sodium can be used for the research of inflammatory diseases.

2380032-29-9
DC44153 MCC7840

MCC7840, a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM. MCC7840 can be used for the research of inflammatory diseases.

1995067-59-8
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