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Home > Research Areas > Cardiovascular Disease > Hypertension

Hypertension

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Cat. No. Product Name Field of Application Chemical Structure
DC8471 CGS 21680 hydrochloride Featured
CGS 21680 hydrochloride is an A2A adenosine receptor agonist (Ki = 27 nM).
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DC10446 (3R,4S,5S)-tert-butyl 3-Methoxy-5-Methyl-4-(MethylaMino)heptanoate hydroc hloride Featured
Diltiazem hydrochloride is a calcium ion influx inhibitor (slow channel blocker or calcium antagonist).
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DC7699 VTP-27999 Featured
VTP-27999 is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.
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DC4108 Sitaxentan sodium Featured
Sitaxentan sodium (TBC-11251) is a selective endothelin receptor-A antagonist with IC50 and Ki of 1.4 nM and 0.43 nM, respectively.
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DC9153 Losartan Potassium Featured
Losartan is an angiotensin II receptor antagonist, competes with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
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DC8901 Azilsartan medoxomil Featured
Azilsartan medoxomil(TAK 491) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of  0.62 nM, which used in the treatment of adults with essential hypertension.
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DCAPI1495 Aliskiren Hemifumarate Featured
Aliskiren hemifumarate(CGP 60536) is a direct renin inhibitor with IC50 of 1.5 nM.
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DC9137 Timolol Maleate Featured
(S)-Timolol maleate, is a potent non-selective β-adrenergic receptor antagonist (Ki values are 1.97 and 2.0 nM for β1 and β2 receptor subtypes respectively).
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DC5177 Nepicastat HCl (SYN-117) Featured
Nepicastat hydrochloride is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.
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DC9666 Ro 46-2005 Featured
Ro 46-2005 is a novel synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220 nM.
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DC7490 Rostafuroxin Featured
Rostafuroxin: an ouabain-inhibitor counteracting specific forms of hypertension.
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DCAPI1496 Ambrisentan Featured
A nonpeptide endothelin ETA receptor antagonist. Antihypertensive.
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DC4210 Azilsartan kamedoxomil Featured
Azilsartan medoxomil is an angiotensin II receptor antagonist indicated for the treatment of mild to moderate essential hypertension.
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DC9380 Cleviprex Featured
Clevidipine(Clevidipine) is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ) under development for treatment of perioperative hypertension.
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DC9160 Cilnidipine Featured
Cilnidipine(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity.
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DCAPI1469 azilsartan Featured
Azilsartan(TAK-536) is a specific and potent angiotensin II type 1 receptor antagonist with IC50 of 2.6 nM.
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DC9185 Candesartan cilexetil Featured
Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.
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DC9178 Ketanserin Tartrate
DC9113 Ketanserin
DCAPI1452 Valsartan
Valsartan is a nonpeptide angiotensin II AT1-receptor antagonist with an IC50 ranging from 39.5 to 116 μM. This in turn causes blood vessel dilation.
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DC11138 Guanabenz acetate
R15A inhibitor.
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DC10324 Omapatrilat
Omapatrilat is a dual inhibitor of the metalloproteases ACE and NEP with Ki values of 0.64 and 0.45 nM, respectively.
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DC9179 Olmesartan MedoxoMil
Olmesartan medoxomil(Olmetec; Benicar; CS 866) is an angiotensin II receptor antagonist which is used as an anti-hypertensive.
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DCAPI1464 Olmesartan
Olmesartan Acid is an angiotensin II receptor antagonist that prevents the binding of angiotensin II, thus preventing vasoconstriction.
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DC9108 Nisoldipine
Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.
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DC9170 Nicardipine hydrochloride
Nicardipine Hcl(YC-93) is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic stroke, traumatic brain injury, and intracerebral hemorrhage.
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DC9191 Metoprolol tartrate
Metoprolol is a cardioselective β1-adrenergic blocking agent.
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DC11315 Manidipine(CV-4093)
Manidipine is a dihydropyridine L- and T-type calcium channel blocker.
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DCAPI1419 Losartan
Losartan is a potent, non peptide antagonist of the angiotensin II receptor type 1. This receptor initiates a signal cascade that causes vasoconstriction. Antagonism of this receptor in turn causes vasodilation by blocking the signal from angiotensin II.
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DC9123 Lisinopril Dihydrate
Lisinopril Dihydrate is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.
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