Home > Inhibitors & Agonists > Proteasome/Ubiquitin > Heat Shock Protein (HSP)
Cat. No. Product name CAS No.
DC9482 17-AAG Featured

17-AAG(NSC 330507; CP 127374) is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells.

DC11919 Arimoclomol Featured

A nontoxic heat shock protein (HSP) coinducer and potentiator of the heat shock response.

DC11920 Arimoclomol maleate Featured

A nontoxic, orally active heat shock protein (HSP) coinducer and potentiator of the heat shock response.

DC12011 KU-32

A novel, novobiocin-based, C-terminal inhibitor of Hsp90 and a potent inducer of Hsp70.

DC11970 KU675

A novel, second-generation C-terminal Hsp90 inhibitor with Kd of 191 and 726 uM for Hsp90α and Hsp90β, respectively.

DC11921 Bimoclomol

A potent heat shock protein coinducer.

DC11616 KUNG94

A potent, selective Grp94 inhibitor with IC50 of 8 nM.

DC11619 KUNG29

A potent, selective Grp94 inhibitor with Kd of 0.2 uM.

DC11618 KUNG38

A potent, selective Grp94 inhibitor with Kd of 0.44 uM.

DC11617 PU-H54 Featured

PU-H54 is potent, selective Grp94 inhibitor.

DC8167 Onalespib(AT13387,ATI13387X) Featured

AT13387 is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity.

DC5202 Luminespib (NVP-AUY922) Featured

AUY922 (NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 1/2.

DC7086 BIIB021(CNF2024) Featured

BIIB021(CNF2024) is an orally available, fully synthetic small-molecule inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively.

DC10498 CCT251236 Featured

CCT251236 is an orally available pirin ligand from a heat shock transcription factor 1 (hsf1) phenotypic screen with an IC50 of 19 nM for inhibition of HSF1-mediated HSP72 induction.

DC8477 VER-49009 Featured

Consistent with inhibition of Hsp90, VER-49009 induces the expression of Hsp27 and Hsp72 while reducing the client proteins C-RAF, B-RAF, survivin, and PRMT5, causing cell cycle arrest and apoptosis.

DC7390 CUDC-305(DEBIO 0932) Featured

Debio 0932 ( CUDC-305 ) is a novel heat shock protein 90 (HSP90) inhibitor trong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L) .

DC7320 Ganetespib(STA-9090) Featured

Ganetespib(STA-9090) is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM in OSA 8 cells.

DC7806 Geldanamycin (NSC122750)

Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association.

DC10837 HS-10 Featured

HS-10 is a novel Hsp90 inhibitor increases the Tm of Hsp90 by 10.5°C.

DC10831 HS-27 Featured

Hs-27 is a Novel Hsp90 Inhibitor, Exhibits Diagnostic and Therapeutic Potential in Triple Negative Breast Cancer.

DC10614 HSF1A Featured

HSF1A is a cell-permeable activator of heat shock transcription factor 1 (HSF1).

DC10344 HSP70-IN-1 Featured

HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC50 of 2.3 μM.

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