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U18666A

  Cat. No.:  DC12075   Featured
Chemical Structure
3039-71-2
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More than 5000 active chemicals with high quality for research!
Field of application
U18666A, a cell permeable drug, is a cholesterol synthesis and transport inhibitor.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 3039-71-2
Chemical Name: U-18666A
SMILES: C[C@@]12[C@]3([H])[C@](CC=C1C[C@@H](OCCN(CC)CC)CC2)([H])[C@@]4([H])[C@@](C)(C(CC4)=O)CC3.Cl
Formula: C25H42ClNO2
M.Wt: 424.06
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: U18666A, a cell permeable drug, is a cholesterol synthesis and transport inhibitor.
Target: Cholesterol[1][2].
In Vitro: U18666A, the antiviral effect is found to result from two events: retarded viral trafficking in the cholesterol-loaded late endosomes/lysosomes and suppresse de novo sterol biosynthesis in treated infected cells. It is also observed an additive antiviral effect of U18666A with C75, a fatty acid synthase inhibitor, suggesting dengue virus relies on both the host cholesterol and fatty acid biosynthesis for successful replication[1][2].
References: [1]. Poh MK, et al. U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication. Antiviral Res. 2012 Jan;93(1):191-8. [2]. Cenedella RJ, et al. Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes. Lipids. 2009 Jun;44(6):477-87.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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