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4SC-202 free base

  Cat. No.:  DC8423  
Chemical Structure
910462-43-0
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More than 5000 active chemicals with high quality for research!
Field of application
4SC-202 is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Phase 1.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 910462-43-0
Chemical Name: (E)-N-(2-aminophenyl)-3-(1-(4-(1-methyl-1H-pyrazol-4-yl)phenylsulfonyl)-1H-pyrrol-3-yl)acrylamide
Synonyms: 4SC-202,4SC 202,4SC202
SMILES: O=C(C=CC1C=CN(S(=O)(C2C=CC(C3C=NN(C)C=3)=CC=2)=O)C=1)NC1C(N)=CC=CC=1
Formula: C23H21N5O3S
M.Wt: 447.51
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: In HeLa cells, 4SC-202 induces hyperacetylation of histone H3 with EC50 of 1.1 μM. 4SC-202 induces a G2/M cell cycle arrest by interfering with the normal development of the mitotic spindle and causing collapsed spindle apparatus and multiple nucleation centres. In addition, 4SC-202 shows a broad anti-proliferative activity towards human cancer cell lines with a mean IC50 of 0.7 μM. In vivo, 4SC-202 has a high oral bioavailability, and shows high metabolic stability and a low plasma clearance. 4SC-202 (120 mg/kg p.o.) shows pronounced and robust anti-tumor activity in both A549 NSCLC xenograft and RKO27 colon carcinoma model. For the detailed information of 4SC-202, the solubility of 4SC-202 in water, the solubility of 4SC-202 in DMSO, the solubility of 4SC-202 in PBS buffer, the animal experiment (test) of 4SC-202, the cell expriment (test) of 4SC-202, the in vivo, in vitro and clinical trial test of 4SC-202, the EC50, IC50,and affinity,of 4SC-202, For the detailed information of 4SC-202, the solubility of 4SC-202 in water, the solubility of 4SC-202 in DMSO, the solubility of 4SC-202 in PBS buffer, the animal experiment (test) of 4SC-202, the cell expriment (test) of 4SC-202, the in vivo, in vitro and clinical trial test of 4SC-202, the EC50, IC50,and affinity,of 4SC-202, Please contact DC Chemicals.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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DC44140 FNDR-20123 FNDR-20123 is an orally active, safe and a first-in-class anti-malarial HDAC inhibitor with IC50s of 31 nM and 3 nM for Plasmodium and human HDAC, respectively. FNDR-20123 exerts anti-malarial activity against Plasmodium falciparum asexual stage (IC50=41 nM) and sexual blood stage (IC50=190 nM for male gametocytes). FNDR-20123 inhibits HDAC1/2/3/6/8 (IC50=25/29/2/11/282 nM) and inhibits Class III HDAC isoforms at nanomolar concentrations.
DC44009 FNDR-20123 free base FNDR-20123 free base is an orally active, safe and a first-in-class anti-malarial HDAC inhibitor with IC50s of 31 nM and 3 nM for Plasmodium and human HDAC, respectively. FNDR-20123 free base exerts anti-malarial activity against Plasmodium falciparum asexual stage (IC50=41 nM) and sexual blood stage (IC50=190 nM for male gametocytes). FNDR-20123 free base inhibits HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 (IC50=25, 29, 2, 11, and 282 nM, respectively) and inhibits Class III HDAC isoforms at nanomolar concentrations.
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