5-Ethynyluridine|CAS 69075-42-9|DC Chemicals

Cas No.:	69075-42-9
Chemical Name:	5-Ethynyluridine
Synonyms:	5-Ethynyluridine;5-Ethynyl uridine;Uridine, 5-ethynyl-;AK163061;QCWBIPKYTBFWHH-FDDDBJFASA-N;AX8294829;1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-ethynylpyrimidine-2,4(1H,3H)-dione;5-Ethynyl-uridine (5-EU);5-Ethynyluridine (5-EU)
SMILES:	O1[C@]([H])(C([H])([H])O[H])[C@]([H])([C@]([H])([C@]1([H])N1C(N([H])C(C(C#C[H])=C1[H])=O)=O)O[H])O[H]
Formula:	C₁₁H₁₂N₂O₆
M.Wt:	268.2228
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	5-Ethynyluridine (5-EU) is a potent cell-permeable nucleoside can be used to label newly synthesized RNA. 5-Ethynyluridine can be used for isolation and sequencing of nascent RNA from neuronal populations in vivo. 5-Ethynyluridine can be used to identify changes in transcription in vivo in nervous system disease models.
In Vivo:	5-Ethynyluridine (75 mM in PBS for 1 µl; intracerebellar injection ) shows a labeling of central nervous system cells in mouse[1]. 5-Ethynyluridine (330-750 µMol/g; i.p.) results in in labelling of nascent RNA in cells of multiple organs and tissues, but not in the central nervous system in mouse[1].
References:	[1]. Van't Sant LJ, et al. In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration. Acta Neuropathol Commun. 2021 May 21;9(1):94. [2]. Jao CY, et al. Exploring RNA transcription and turnover in vivo by using click chemistry. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15779-84.

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