N-(p-Amylcinnamoyl) anthranilic Acid (ACA)|cas 110683-10-8|DC Chemicals

Cas No.:	110683-10-8
Chemical Name:	Benzoic acid,2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-
Synonyms:	Benzoic acid,2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-;ACA;N-(p-amylcinnamoyl) Anthranilic Acid;N-(P-AMYLCINNAMOYL)- ANTHRANILIC ACID;4-amylcinnamoylanthranilicacid;N-(P-AMYLCINNAMOYL)ANTHRANILIC ACID;N-(p-Amylcinnamoyl) anthranilic Acid (ACA);2-[[(E)-3-(4-PENTYLPHENYL)PROP-2-ENOYL]AMINO]BENZOIC ACID
SMILES:	O=C(NC1C=CC=CC=1C(O)=O)/C=C/C1C=CC(CCCCC)=CC=1
Formula:	C₂₁H₂₃NO₃
M.Wt:	337.41222
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker[1][2]. N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is also an effective reversible inhibitor of calcium-activated chloride channels, has potential to treat arrhythmia[3].
Target:	PLA2[1][2]. TRP channel[1][2].Calcium-activated chloride channels[3].
In Vitro:	N-(p-amylcinnamoyl) Anthranilic Acid (ACA; 20 μM) completely blocks ADPR-induced whole-cell currents and H2O2-induced Ca2+ signals (IC50=1.7 μM) in HEK293cells transfected with human TRPM2[1]. N-(p-amylcinnamoyl) Anthranilic Acid (ACA; 20 μM) also blocks currents through human TRPM8 and TRPC6 expressed in HEK293 cells[1]. N-(p-amylcinnamoyl) Anthranilic Acid (ACA) modulates the activity of different TRP channels independent of PLA22 inhibition[1].
References:	[1]. Kraft R, et al. Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid. Br J Pharmacol. 2006 Jun;148(3):264-73. [2]. Harteneck C, et al. N-(p-amylcinnamoyl)anthranilic acid (ACA): a phospholipase A(2) inhibitor and TRP channel blocker. Cardiovasc Drug Rev. 2007 Spring;25(1):61-75. [3]. Gwanyanya A, et al. Inhibition of the calcium-activated chloride current in cardiac ventricular myocytes by N-(p-amylcinnamoyl)anthranilic acid (ACA). Biochem Biophys Res Commun. 2010 Nov 19;402(3):531-6.

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