AG-024322(AG024322)|CDK inhibitor|DC Chemicals

Cas No.:	837364-57-5
Chemical Name:	N-[[5-[(3E)-3-(4,6-difluorobenzimidazol-2-ylidene)-1,2-dihydroindazol-5-yl]-4-methylpyridin-3-yl]methyl]ethanamine
Synonyms:	AG-024322; AG24322; AG 024322.
SMILES:	CC1=C(CNCC)C=NC=C1C2=CC3=C(NN=C3C4=NC5=CC(F)=CC(F)=C5N4)C=C2
Formula:	C₂₃H₂₀F₂N₆
M.Wt:	418.441906
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

In vitro: Ki = 1–3 nM (CDK1, CDK2 and CDK4)141; displayed CDK selectivity over non-CDKs141; arrested multiple stages of the cell cycle and induced apoptosis in various human tumour cell lines (IC50 = 30–200 nM)141 bulletDisplayed dose-dependent antitumour activity in mice bearing human tumour xenografts142 bulletIntravenous toxicity in cynomolgus monkey included bone marrow hypocellularity, lymphoid depletion and vascular irritation (at doses greater than or equal to 6 mg per kg); the no-adverse-effect dose was 2 mg per kg143For the detailed information of AG-024322, the solubility of AG-024322 in water, the solubility of AG-024322 in DMSO, the solubility of AG-024322 in PBS buffer, the animal experiment (test) of AG-024322, the cell expriment (test) of AG-024322, the in vivo, in vitro and clinical trial test of AG-024322, the EC50, IC50,and Affinity of AG-024322, Please contact DC Chemicals.

Cat. No.	Product name	Field of application
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