Aripiprazole Lauroxil | LAI Antipsychotic

Cas No.:	1259305-29-7
Chemical Name:	(7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2-oxo-3,4-dihydroquinolin-1(2H)-yl)methyl dodecanoate
Synonyms:	RDC 3317; RDC-3317; RDC3317; ALKS9072; ALKS-9072; ALKS 9072;Aripiprazole lauroxil; Aristada.
SMILES:	CCCCCCCCCCCC(=O)OCN1C(=O)CCC2=C1C=C(C=C2)OCCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl
Formula:	C₃₆H₅₁Cl₂N₃O₄
M.Wt:	660.721
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Aripiprazole lauroxil, an N-acyloxymethyl prodrug of aripiprazole, is a Long-acting injectable (LAI) typical antipsychotic for schizophrenia. Aripiprazole lauroxil is cleaved by body’s enzyme esterase to N-hydroxymethyl aripiprazole (plus lauric acid) and then to aripiprazole (plus formaldehyde), no toxicity[1].

In Vivo:

Aripiprazole lauroxil (intravenous administration; 1.87 mg/ml) bioconversion in vivo involves the formation of an intermediate, N-hydroxymethyl aripiprazole, the in vitro data indicates a high bioconversion of aripiprazole lauroxil, thus, the concentration of N-hydroxymethyl aripiprazole observed in the animals dosed with aripiprazole lauroxil is surprisingly high[1]. Animal Model: Female Sprague Dawley rats[1] Dosage: 1.87 mg/ml Administration: Blood samples is taken at 5, 15, 30 min and 1, 2, 4, 6, 8 and 24 h after administration Result: Exhibits an clearance: 0.32 ± 0.11 L/h/kg.

MSDS

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MSDS_12302_DC28247_1259305-29-7

COA

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