BK-1361|cyclo-RLsKDK|CAS 1975145-82-4

Cas No.:	1975145-82-4
Chemical Name:	cyclo-RLsKDK; s=D-serine
Synonyms:	BK 1361;BK1361;cyclo-RLsKDK
SMILES:	CC(C)C[C@@H]1C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N1)CCCN=C(N)N)CCCCN)CC(=O)O)CCCCN)CO
Formula:	C₃₁H₅₇N₁₁O₉
M.Wt:	727.865
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

Description:

BK-1361(BK1361, cyclo-RLsKDK) is a cyclic peptide with RLsKDK (s=D-serine) that functions as a potent, selective inhibitor of ADAM8 with IC50 of 120 nM; displays no significant activity against ADAM 9, 10, 12, 17 , as well as MMP-2, -9, and -14 at 10 uM; inhibit shedding of CD23 with IC50 of 182 nM in cell-based shedding assays, reduces migration/invasion of pancreatic cancer cells and less ERK1/2 and MMP activation, causes change in cell morphology; decreases tumour burden and metastasis of implanted pancreatic tumour cells and provides improved metrics of clinical symptoms and survival in Kras(G12D)-driven mouse model of PDAC.

References:

References 1. Schlomann U, et al. Nat Commun. 2015 Jan 28;6:6175. 2. Chen J, et al. Sci Rep. 2016 Jul 26;6:30451. 3. Yim V, et al. Bioorg Med Chem. 2016 Sep 15;24(18):4032-4037. View Related Products by Target Matrix Metalloproteinase (MMP)

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
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DC37245	Piperonyl butoxide	Piperonyl butoxide (PBO) is an organic compound used as a component of pesticide formulations. It is a waxy white solid. It is a synergist. That is, despite having no pesticidal activity of its own, it enhances the potency of certain pesticides such as carbamates, pyrethrins, pyrethroids, and rotenone.[1] It is a semisynthetic derivative of safrole.
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BK-1361(cyclo(RLsKDK))