BM212

Cas No.:	146204-42-4
Chemical Name:	Piperazine,1-[[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl]-4-methyl-
Synonyms:	Piperazine,1-[[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl]-4-methyl-;BM-212;1-[[1,5-bis(4-chlorophenyl)-2-methylpyrrol-3-yl]methyl]-4-methylpiperazine;BM 212;BM 212 (bactericide);BM212
SMILES:	CN1CCN(CC2=C(C)N(C3=CC=C(Cl)C=C3)C(C4=CC=C(Cl)C=C4)=C2)CC1
Formula:	C23H25Cl2N3
M.Wt:	414.3707
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	BM212 exerts bactericidal activity against intracellular bacilli residing, completely inhibits the intracellular mycobacteria.
In Vitro:	BM212 is inhibitory to drug-resistant mycobacteria and also exerted bactericidal activity against intracellular bacilli residing in the U937 human histiocytic lymphoma cell line.[1] BM212 completely inhibits the intracellular mycobacteria.BM212 had inhibitory activity against all strains tested, with MICs between 0.7 and 1.5 μg/ml.[2]
References:	[1]. Poce G et al. Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection. PLoS One. 2013;8(2) [2]. Deidda D et al. Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains. Antimicrob Agents Chemother. 1998 Nov;42(11):3035-7. [3]. Deidda D et al. Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains.