CRANAD-2|CAS 1193447-34-5|DC Chemicals

Cas No.:	1193447-34-5
Chemical Name:	CRANAD 2
Synonyms:	CRANAD 2;CRANAD-2;(T-4)-[(1E,6E)-1,7-bis[4-(Dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-?O3,?O5]difluoroboron
SMILES:	CN(C)C1=CC=C(C=C1)\C=C/C2O[B-](F)(F)O\C(=C/C=C3C=CC(=[N+](C)C)C=C3)C=2
Formula:	C₂₃H₂₅BF₂N₂O₂
M.Wt:	410.264612913132
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

CRANAD-2 is a difluoroboron-derivatized curcumins as near-infrared probe for in vivo detection of amyloid-beta deposits. Upon interacting with Abeta aggregates, CRANAD-2 undergoes a range of changes, which include a 70-fold fluorescence intensity increase, a 90 nm blue shift (from 805 to 715 nm), and a large increase in quantum yield. Moreover, this probe also shows a high affinity for Abeta aggregates (K(d) = 38.0 nM), a reasonable log P value (log P = 3), considerable stability in serum, and a weak interaction with albumin. After intravenous injection of this probe, 19-month-old Tg2576 mice exhibited significantly higher relative signal than that of the control mice over the same period of time.

MSDS

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MSDS_15342_DC33031_1193447-34-5

COA

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