D159687|cas 1155877-97-6|DC Chemicals

Cas No.:	1155877-97-6
Chemical Name:	1-(4-((3'-Chloro-6-methoxy-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea
Synonyms:	1-(4-((3'-Chloro-6-methoxy-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea;[4-[[3-(3-chlorophenyl)-4-methoxyphenyl]methyl]phenyl]urea;[4-(3'-Chloro-6-methoxy-biphenyl-3-ylmethyl)-phenyl]-urea;AK136191;D-159687;SureCN3466522;UNII-4T436CO8BT;Urea, N-(4-((3'-chloro-6-methoxy(1,1'-biphenyl)-3-yl)methyl)phenyl)-;D159687
SMILES:	COC1=C(C2=CC(Cl)=CC=C2)C=C(CC3=CC=C(NC(N)=O)C=C3)C=C1
Formula:	C₂₁H₁₉N₂O₂Cl
M.Wt:	366.84076
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	D159687 is a selective PDE4D inhibitor[1].
In Vivo:	D159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques[2]. Animal Model: Female Cynomolgus macaques (4–6 year old) [2] Dosage: 0.05, 0.5, 5 mg/kg Administration: Oral daily for a week Result: A potential recruitment or enhancement of synaptic function with increased task difficulty.
In Vitro:	D159687 (1 μM, 0-24 hours) induces a transient increase in CREB phosphorylation which peaked at 6 hours after treatment[1]. D159687 (0.01-1 μM, 6 hours) causes optimal CREB phosphorylation at 1 μM[1]. Western Blot Analysis[1] Cell Line: HT-22 (mouse hippocampal cell line) Concentration: 1 μM Incubation Time: 0, 1, 3, 6, 12, 24 hours Result: Induced a transient increase in CREB phosphorylation which peaked at 6 hours after treatment. Western Blot Analysis[1] Cell Line: HT-22 (mouse hippocampal cell line) Concentration: 0.01 μM, 0.1 μM, 1 μM Incubation Time: 6 hours Result: CREB phosphorylation was optimal at 1 μM.

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