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SCB-4380

  Cat. No.:  DC11818   Featured
Chemical Structure
915-67-3
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More than 5000 active chemicals with high quality for research!
Field of application
SCB-4380 (SCB 4380, SCB4380) is the first potent, selective inhibitor for PTPRZ (protein tyrosine phosphatase receptor-type Z) with IC50 of 0.4 uM against human Z-ICR-catalyzed hydrolysis. SCB-4380 also strongly inhibits PTPRG (IC50=0.4 uM), and shows little inhibition on PTPRA, PTPRM, PTPRS, PTPRB, PTPN1 and PTPN6. SCB-4380 inhibites PTPRZ activity in C6 glioblastoma cells, and suppresse cell migration and proliferation in vitro and tumor growth in a rat allograft model.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 915-67-3
Chemical Name: Trisodium 3-hydroxy-4-[(4-sulfonato-1-naphthyl)diazenyl]-2,7-naphthalenedisulfonate
Synonyms: SCB 4380;SCB4380
SMILES: [Na+].[Na+].[Na+].C1=C2C(C=CC(S([O-])(=O)=O)=C2)=C(/N=N/C2=C3C(C=CC=C3)=C(S([O-])(=O)=O)C=C2)C(O)=C1S([O-])(=O)=O
Formula: C20H11N2Na3O10S3
M.Wt: 604.473054170609
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: 1. Fujikawa A, et al. Sci Rep. 2016 Feb 9;6:20473.
Description: SCB-4380 (SCB 4380, SCB4380) is the first potent, selective inhibitor for PTPRZ (protein tyrosine phosphatase receptor-type Z) with IC50 of 0.4 uM against human Z-ICR-catalyzed hydrolysis. SCB-4380 also strongly inhibits PTPRG (IC50=0.4 uM), and shows little inhibition on PTPRA, PTPRM, PTPRS, PTPRB, PTPN1 and PTPN6. SCB-4380 inhibites PTPRZ activity in C6 glioblastoma cells, and suppresse cell migration and proliferation in vitro and tumor growth in a rat allograft model.
Target: PTPRZ
References: 1. Fujikawa A, et al. Sci Rep. 2016 Feb 9;6:20473.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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