PNU 96415E|PNU-96415E;PNU96415E

Cas No.:	170856-41-4
Chemical Name:	(±)-1-(4-Fluorophenyl)-4-[2-(isochroman-1-yl)ethyl]piperazine dihydrochloride
Synonyms:	PNU-96415E;PNU96415E
SMILES:	N(C1=CC=C(F)C=C1)1CCN(CCC2C3=C(C=CC=C3)CCO2)CC1.[H]Cl.[H]Cl
Formula:	C₂₁H₂₅N₂OF^.₂[HCl]
M.Wt:	413.35628
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potential antipsychotic agent that binds selectively to D4 and 5-HT2A receptors with Ki of 3.0 and 5.8 nM, respectively; has relatively lower affinities for D1, D2, D3, 5-HT1A and α2 receptors (Ki=200-400 nM), and no affitnity for muscarinic receptors; inhibits exploratory locomotor activity in mice and rats, and antagonizes d-amphetamine-induced locomotor stimulation in rats; also selectively inhibits GBM neural stem cells (GNS) growth and promotes differentiation of normal neural stem cells.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC47684	Dopamine D3 receptor antagonist-1	Dopamine D3 receptor antagonist-1 is a dopamine D3 receptor-selective or multitarget bitopic ligand (Ki = 1.58 nM) potentially useful for central nervous system disorders.
DC47682	Dopamine D3 receptor antagonist-2	Dopamine D3 receptor antagonist-2 is a dopamine D3 receptor-selective (Ki = 2.16 nM) or multitarget bitopic ligand potentially useful for central nervous system disorders.
DC47266	SKF83822 hydrobromide	SKF83822 hydrobromide is a potent dopamine D1 receptor agonist. SKF83822 hydrobromide activates Gs/olf/adenylyl cyclase (AC)-coupled D1 receptors, but not phospholipase C (PLC)-coupled D1-like receptors.
DC47254	BP 897	BP 897 is a potent and partial dopamine D3 receptor agonist and a weak D2 receptor antagonist. BP 897 displays a high affinity at the dopamine D3 receptor (Ki=0.92 nM) and a 70 times lower affinity at the D2 receptor (Ki=61 nM). BP 897 exhibits selective inhibition of cocaine-seeking behavior.
DC47173	Roxindole	Roxindole (EMD 49980), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT1A agonist and 5-HT uptake inhibitor with high affinity for 5-HT1A (IC50=0.9 nM). Antipsychotic and antidepressant activities.
DC47110	Deudomperidone	Domperidone-d4 is a deuterium labeled Domperidone (R33812).Domperidone is a selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine.
DC47054	Trazpiroben	Trazpiroben (TAK-906) is a dopamine D2/D3 receptor antagonist used for chronic research of moderate-to-severe gastroparesis.
DC47044	Onzigolide	Onzigolide (BIM-23A760), a chimeric dopamine-somatostatin compound, shows potent agonist activity at both DA type 2 (D2R) and SST type 2 (SSTR2) receptors.
DC47014	Medifoxamine	Medifoxamine is a monoamine re-uptake inhibiting antidepressive drug which preferentially inhibits dopamine reuptake.
DC46841	Quinelorane dihydrochloride	Quinelorane dihydrochloride (LY163502) is a potent dopamine D3/D2 receptor agonist. Quinelorane has the potential for neurological and psychiatric disorders research.