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Indotecan(LMP400)

  Cat. No.:  DC20276   Featured
Chemical Structure
915303-09-2
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More than 5000 active chemicals with high quality for research!
Field of application
Indotecan(LMP400) is a novel selective and potent topoisomerase I inhibitor with potential anticancer activitity.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 915303-09-2
Chemical Name: 2,3-Dimethoxy-6-[3-(4-morpholinyl)propyl]-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione
Synonyms: LMP400;LMP-400
SMILES: COC1=C(C=C2C(=C1)C3=C(C4=CC5=C(C=C4C3=O)OCO5)N(C2=O)CCCN6CCOCC6)OC
Formula: C26H26N2O7
M.Wt: 478.501
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Indotecan (LMP-400) is a potent topoisomerase 1(Top1) inhibitor with IC50 values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively.
Target: IC50：300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively[1].
References: [1]. Seol Y, et al. Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors. Mol Cancer Ther. 2015 Nov;14(11):2552-9.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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