Mizagliflozin|DSP-3235;KGA-3235;GSK-1614235

Cas No.:	666843-10-3
Chemical Name:	Mizagliflozin
Synonyms:	Mizagliflozin;1X96A704XV;3-((3-(4-((5-isopropyl-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1H-pyrazol-4-yl)methyl)-3-methylphenoxy)propyl)amino)-2,2-dimethylpropanamide;Mizagliflozin [INN];Mizagliflozin [WHO-DD];GTPL9547;s8939;Q27253060;2,2-dimethyl-3-[3-[3-methyl-4-[[3-propan-2-yl-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2H-pyrazol-4-yl]methyl]phen
SMILES:	O1[C@H]([C@@H]([C@H]([C@@H]([C@H]1CO)O)O)O)OC1C(CC2C=CC(=CC=2C)OCCCNCC(C(N)=O)(C)C)=C(C(C)C)NN=1
Formula:	C₂₈H₄₄N₄O₈
M.Wt:	564.6710
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Inoue T, et al. Mizagliflozin, a novel selective SGLT1 inhibitor, exhibits potential in the amelioration of chronic constipation. Eur J Pharmacol. 2017 Jul 5;806:25-31. [2]. Ohno H, et al. Absorption, disposition, metabolism and excretion of [14C]mizagliflozin, a novel selective SGLT1 inhibitor, in rats. Xenobiotica. 2019 Apr;49(4):463-473.

Description:

Mizagliflozin (DSP-3235, KGA-3235, GSK-1614235) is a potent, selective, orally active SGLT1 inhibitor with Ki of 27 nM, displays >350-fold selectivity over SGLT2; increases stool frequency and loosens stool consistency in phase I study; increases fecal wet weight in a dog model of loperamide-induced constipation and a rat model of low-fiber-diet-induced constipation, similar to lubiprostone. Diabetes Phase 1 Clinical

References:

References 1. Inoue T, et al. Eur J Pharmacol. 2017 Jul 5;806:25-31. View Related Products by Target SGLT Diabetes

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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