GR-73632|GR73632|CAS 133156-06-6|DC Chemicals

Cas No.:	133156-06-6
Chemical Name:	FFPLM (Modifications: Phe-1 = delta-Aminovaleryl-Phe, Leu-4 = (methyl)Leu, Met-5 = C-terminal amide)
Synonyms:	GR73632
SMILES:	CSCC[C@@H](C(N)=O)NC([C@H](CC(C)C)N(C([C@H]1N(C([C@H](CC2=CC=CC=C2)NC([C@H](CC3=CC=CC=C3)NC(CCCCN)=O)=O)=O)CCC1)=O)C)=O
Formula:	C₄₀H₅₉N₇O₆S
M.Wt:	766.01
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Sakurada C, et al. Spinal actions of GR73632, a novel tachykinin NK1 receptor agonist. Peptides. 1999;20(2):301-4. [2]. Costantini VJ, et al. The NK1 receptor antagonist aprepitant attenuates NK1 agonist-induced scratching behaviour in the gerbil after intra-dermal, topical or oral administration. Exp Dermatol. 2015 Apr;24(4):312-4.

Description:	GR-73632 is a novel tachykinin neurokinin 1 (NK-1) receptor agonist[1]. GR-73632 acts directly on the peripheral terminals of primary sensory neurons through NK1 receptor which convey itch signals[2].
Target:	IC50: NK-1 receptor[1]
References:	[1]. Sakurada C, et al. Spinal actions of GR73632, a novel tachykinin NK1 receptor agonist. Peptides. 1999;20(2):301-4. [2]. Costantini VJ, et al. The NK1 receptor antagonist aprepitant attenuates NK1 agonist-induced scratching behaviour in the gerbil after intra-dermal, topical or oral administration. Exp Dermatol. 2015 Apr;24(4):312-4.

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