BMS-955176|GSK-3532795;BMS955176

Cas No.:	1392312-45-6
Chemical Name:	BMS-955176 free base
Synonyms:	BMS-955176(free base);GSK3532795
SMILES:	C1C(C(=O)O)=CC=C(C2=CC[C@]3(C)[C@@]4([H])CC[C@]5([H])[C@@]6([H])[C@H](C(C)=C)CC[C@]6(NCCN6CCS(=O)(=O)CC6)CC[C@@]5(C)[C@]4(C)CC[C@@]3([H])C2(C)C)C=1
Formula:	C₄₂H₆₂N₂O₄S
M.Wt:	691.028
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

BMS-955176 (GSK-3532795) is a second-generation HIV-1 maturation inhibitor that exhibits potent activity (EC50=3.9±3.4 nM) against a library (n=87) of gag/pr recombinant viruses; exhibits median EC50 of 21 nM toward a library of subtype B clinical isolates assayed in PBMCs; inhibits HIV-1 protease cleavage at the CA/SP1 junction within Gag in VLPs and in HIV-1-infected cells, and binds reversibly and with high affinity to assembled Gag in purified HIV-1 VLPs; has a greatly improved preclinical profile compared to that of Bevirimat. HIV Infection Phase 2 Clinical

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