I-191|I191|CAS 1690172-25-8|DC Chemicals

Cas No.:	1690172-25-8
Chemical Name:	CID 117977934
Synonyms:	4-[8-tert-butyl-6-(4-fluorophenyl)imidazo[1,2-b]pyridazine-2-carbonyl]-3,3-dimethylpiperazin-2-one;4-(8-tert-Butyl-6-(4-fluorophenyl)imidazo[1,2-b]pyridazine-2-carbonyl)-3,3-dimethylpiperazin-2-one;GTPL10268;4-(8-(tert-Butyl)-6-(4-fluorophenyl)imidazo[1,2-b]pyridazine-2-carbonyl)-3,3-dimethylpiperazin-2-one;CID 117977934;I-191
SMILES:	FC1C([H])=C([H])C(=C([H])C=1[H])C1C([H])=C(C2=NC(=C([H])N2N=1)C(N1C([H])([H])C([H])([H])N([H])C(C1(C([H])([H])[H])C([H])([H])[H])=O)=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
Formula:	C₂₃H₂₆FN₅O₂
M.Wt:	423.4832
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	I-191 is a protease-activated receptor 2 (PAR-2) signaling pathway inhibitor extracted from patent WO2015048245A1. I-191 inhibits PAR-2 activators such as SLIGKV, Trypsin, and Thrombin with IC50s of 0.0014 μM, 0.0023 μM, 0.32 μM, respectively[1].
Target:	IC50: 0.0014 μM (SLIGKV), 0.0023 μM (Trypsin), 0.32 μM (Thrombin)[1]
References:	[1]. Luc J. Farmer, et al. Imidazopyridazines useful as inhibitors of the par-2 signaling pathway. WO2015048245A1.

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