Inflachromene |CAS 908568-01-4|DC Chemicals

Cas No.:	908568-01-4
Chemical Name:	Inflachromene
Synonyms:	Inflachromene;AOB6225;5,12b-Dihydro-10-hydroxy-7,7-dimethyl-2-phenyl-1H,7H-[1]benzopyrano[4,3-c][1,2,4]triazolo[1,2-a]pyridazine-1,3(2H)-dione (ACI);ICM
SMILES:	O=C1N2CC=C3C(C)(C)OC4C(=CC=C(C=4)O)C3N2C(=O)N1C1C=CC=CC=1
Formula:	C₂₁H₁₉N₃O₄
M.Wt:	377.393265008926
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Inflachromene (ICM) is a microglial inhibitor with anti-inflammatory effects, directly binds high mobility group protein 1 (HMGB1) and HMGB2 and reduces their cytoplasmic accumulation in microglial cells; blocks the sequential processes of cytoplasmic localization and extracellular release of HMGBs by perturbing its post-translational modification; effectively downregulates proinflammatory functions of HMGB and reduces neuronal damage in vivo.

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