Seltorexant|MIN-202;JNJ-42847922;JNJ-922

Cas No.:	1293281-49-8
Chemical Name:	Seltorexant
Synonyms:	Seltorexant;[2-(4,6-dimethylpyrimidin-2-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-[2-fluoro-6-(triazol-2-yl)phenyl]methanone;Seltorexant [USAN];Seltorexant (USAN/INN);GTPL9308;BDBM118454;Methanone, (5-(4,6-dimethyl-2-pyrimidinyl)hexahydropyrrolo(3,4-C)pyrrol-2(1H)-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)-;SB19652;JNJ42847922;D11269;US8653263, 107;((3aR,6aS)-5-(4,6-dimethylpyrimid;DA-57786;MS-26993;AKOS032954213;[5-(4,6-Dimethyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(2-fluoro-6-[1,2,3]triazol-2-yl-phenyl)-methanone;JNJ-42847922;HY-109012;E77321;SCHEMBL1671257;EX-A4759;CS-0030510;SQOCEMCKYDVLMM-UHFFFAOYSA-N;JNJ-922;CHEMBL3597971;EN300-22831084;((3aR,6aS)-5-(4,6-dimethylpyrimidin- 2-yl)hexahydropyrrolo(3,4-c)pyrrol-2(1H)-yl)(2-fluoro- 6-(2H-1,2,3-triazol-2-yl)phenyl)methanone;(5-(4,6-Dimethylpyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)methanone;2-{5-[2-fluoro-6-(2H-1,2,3-triazol-2-yl)benzoyl]-octahydropyrrolo[3,4-c]pyrrol-2-yl}-4,6-dimethylpyrimidine;AC-36998;1293281-49-8
SMILES:	FC1C=CC=C(C=1C(N1CC2CN(C3N=C(C)C=C(C)N=3)CC2C1)=O)N1N=CC=N1
Formula:	C₂₁H₂₂FN₇O
M.Wt:	407.444086551666
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent, selective, orally active orexin-2 receptor (OX2R) antagonist with pKi of 8.0 and 8.1 for human and rat OX2R, respectively; displays an 2-log selectivity over OX1R, and shows no significant affinity for 50 receptor/transporter/ion channel (<50% inhibition at 1 uM); reduces the latency to non–rapid eye movement (NREM) sleep and prolongs NREM sleep time in rats (3–30 mg/kg).Sleep DisorderPhase 2 Clinical

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