SU-909|CAS 2126749-48-0;IKKα-IN-48|DC Chemicals

Cas No.:	2126749-48-0
Chemical Name:	4-(2-Amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzenesulfonamide
Synonyms:	BDBM50257823;4-(2-Amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzenesulfonamide
SMILES:	S(C1C=CC(=CC=1)C1=C2C(C#N)=CNC2=NC(N)=N1)(N)(=O)=O
Formula:	C₁₃H₁₀N₆O₂S
M.Wt:	314.322499752045
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Anthony NG, et al. J Med Chem. 2017 Aug 24;60(16):7043-7066.

Description:	SU-909 (SU909, IKKα-IN-48) is a potent, selective IKKα inhibitor with Ki of 0.08±0.07 uM, 10-20-fold selectivity over IKKβ (IC50=1.0±0.28 uM); inhibits FCS-stimulated phosphorylation of p100 in U2OS cells with IC50 of 8.8 uM, inhibits the noncanonical NF-kB pathway without affecting IKKβ-dependent IKappa-Bα loss in the canonical pathway.
References:	References 1. Anthony NG, et al. J Med Chem. 2017 Aug 24;60(16):7043-7066. View Related Products by Target IκB kinase (IKK)

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